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Basic information

CohesinDB ID: CDBP00416753

Locus: chr21-31870626-31876394

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, ENCSR198ZYJ, GSE130135, ENCSR199XBQ, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE143937, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT

Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, TC-32, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, Ishikawa, Kelly, GM12890, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, HUES64, MCF-7, GM12892, THP-1, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, GM19238, BGO3, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 59% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.367

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 71% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "13_ReprPC": 15%, "14_ReprPCWk": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SS18, ZFX, NME2, ZBTB48, DDX5, SMARCC1, YY1, ZNF384, NEUROD1, MYC, BRG1, GR, RAD21, SP140, ARNT, RXRA, OTX2, GATA3, PRDM9, GABPA, MAX, ZSCAN4, NR3C1, CEBPB, TEAD1, NR2F2, EZH2, ESR1, PITX3, ZNF334, ZNF652, CTCF, EP300, SP1, AR, PAX3-FOXO1, GATA2, SIX2, FLI1, BRD4, MAZ, TEAD4, ETV5

Target gene symbol (double-evidenced CRMs): SYNJ1,URB1,MIS18A,CFAP298,HUNK,SCAF4,TIAM1,CFAP298-TCP10L

Function elements

Human SNPs: Protein_quantitative_trait_loci_(liver)

Number of somatic mutations (coding): 28

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000156299, ENSG00000156304, ENSG00000142149, ENSG00000159055, ENSG00000142207, ENSG00000265590, ENSG00000159079, ENSG00000159082,

eachgene

Deatailed information for cohesin site CDBP00416753