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Basic information

CohesinDB ID: CDBP00416882

Locus: chr21-32256207-32261140

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, T-47D, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 81% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.144

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "7_Enh": 29%, "5_TxWk": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, ZNF426, ZNF697, ZNF660, SOX2, XBP1, PATZ1, FOXA1, ZNF101, SUZ12, PBX2, UBTF, HDGF, ATF3, NFIC, ZC3H8, ZFP64, CTCFL, CHD7, PRDM1, RUNX3, PRDM12, ZNF273, MXD4, ZNF189, MITF, ZNF467, ZNF629, MYOG, JMJD1C, TRIM28, BCLAF1, RBM39, KLF6, NFE2L2, ZNF217, ESR1, PITX3, USF2, ZNF561, CTCF, JUN, TCF12, EP300, BAF155, E4F1, LMO1, MNT, SOX5, ZNF577, PAX8, SOX4, RYBP, E2F6, IRF4, RFX5, DEK, PRKDC, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF555, GATAD2A, PDX1, RBPJ, TFAP2C, EHMT2, GLIS1, JARID2, NANOG, CHD8, ZNF425, POU2F2, MYCN, POU5F1, ZNF263, CDK7, RUNX1T1, CTBP1, ZSCAN21, ZBTB17, ZBTB48, DUX4, ZNF433, BRD1, SRF, GATAD1, ERG2, ARID3A, ERG, ZBTB21, HOXC5, USP7, MIER1, ASCL1, ETS1, MYC, TRIP13, SMARCA4, RFX1, TSHZ1, RAD21, ZNF2, GRHL3, EOMES, ZNF24, PROX1, FOXK2, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, RCOR1, NFE2, ZNF639, NR2F6, ARNTL, VDR, NR3C1, ZNF750, CEBPB, MIER3, KMT2A, CREB1, CCAR2, ZBTB11, EZH2, JMJD6, GRHL2, ZNF292, EBF3, ZNF48, SPI1, HBP1, EHF, MIXL1, KLF17, KDM5A, ZNF664, ZNF202, GATA2, FLI1, DRAP1, MXI1, MRTFB, ZC3H11A, ZNF554, ETV5, CC2D1A, RUNX1, THAP11, SMC1A, ZBTB24, CEBPA, NKX2-2, SIN3A, ZFX, SMAD3, REPIN1, ZFP37, ZNF654, CBX8, ERG3, ZNF770, TET2, TRIM22, SMARCC1, PRDM10, TWIST1, MEF2A, ZNF18, ZBTB2, ZNF384, ZNF35, RUNX2, GATA4, OSR2, ZNF184, PBX4, ARNT, NRF1, BACH1, ZNF781, HMGB2, ATF2, ZEB2, ZNF518A, SMAD4, PBX3, MAFB, FOXJ2, CHD1, FOS, HMGXB4, FOXM1, CDK8, MED1, ZBTB8A, ZEB1, TEAD3, ZXDB, ZNF558, SCRT2, PIAS1, CEBPD, MYB, SMAD1, ZNF680, KLF9, NCOA1, L3MBTL2, MBD1, KLF16, USF1, SP1, BCL11A, MAFK, HNF4A, ARID2, REST, ZBTB7A, IKZF5, BCOR, FOXP1, ZNF623, SMC3, ZNF34, STAG2, STAG1, ZNF394, NFATC3, FOXA2, MTA3, TBL1X, CHD2, SS18, ZNF600, ZNF692, GTF2B, ZNF30, MIER2, ZSCAN16, ZNF493, WT1, ZNF574, CDK9, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, NEUROD1, JUNB, AHR, ZNF266, BRG1, SP140, ZIC2, HIF1A, SKIL, ZFP36, OTX2, GATA3, BATF, TAL1, MAX, ZNF143, GATA1, HAND2, CBX2, ZFP69B, KLF4, SP7, CEBPG, GFI1B, ZNF223, TCF7L2, ZNF791, KDM5B, TP53, ZBTB6, ZNF213, ZNF334, NFKB1, MYOD1, ZNF140, BRD2, ELF3, ARRB1, BHLHE40, AR, ARID4B, TAF1, ZNF324, RBAK, EGLN2, ZNF366, ZBTB42, RB1, HSF1, RNF2, NCOR1, BRD4, JUND, ILF3, ZBTB26, SCRT1, MAZ, ZSCAN23, BRCA1, ZFP42, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): CFAP298-TCP10L,HUNK,SCAF4,TIAM1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 16

Related genes and loops

Related gene: ENSG00000156299, ENSG00000156304, ENSG00000142149, ENSG00000265590,

eachgene

Deatailed information for cohesin site CDBP00416882