- Basic information
- CohesinDB ID: CDBP00416894
- Locus: chr21-32298101-32299158
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Data sourse: GSE67783, GSE86191, GSE111913, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EDW, ENCSR917QNE
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Cell type: Fibroblast, HCT-116, Hep-G2, RT-112, K-562, Liver, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SMC1,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"5_TxWk": 45%,
"15_Quies": 38%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, SOX2, FOXA1, CBFB, TP63, JMJD1C, KLF6, RBM39, RCOR2, ESR1, USF2, CTCF, TCF12, EP300, E2F1, TEAD4, GATAD2A, RBPJ, EED, ZNF263, MYCN, RUNX1T1, ID3, ZBTB48, ERG, OGG1, ONECUT1, SMARCA4, ZKSCAN2, ARID1B, GRHL3, RXRA, GABPA, STAT3, ZNF614, XRCC5, IKZF1, RCOR1, MIER3, NR2F6, ARNTL, NR3C1, CEBPB, GABPB1, SPI1, MIXL1, SSRP1, ZSCAN29, FLI1, THAP11, SMC1A, BCL6, CEBPA, SOX13, ZFX, RUNX2, ZNF48, PRDM9, SMAD4, CBFA2T3, MED1, TEAD3, CEBPD, MYB, KDM6B, KLF9, RBM22, USF1, SP1, HNF4A, IKZF5, REST, ASH2L, HNRNPLL, AATF, SMC3, STAG1, NFATC3, TRP47, CBFA2T2, PPARG, FOXA2, AGO1, PAF1, HOXB13, ZNF580, KDM1A, YY1, RELA, SP140, TAL1, MAX, GATA1, AGO2, PLAG1, CEBPG, NR2F2, NEUROG2, NR2F1, ARID4B, HEXIM1, ZBTB26, HSF1, BRD4, JUND, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): SYNJ1,CFAP298-TCP10L,TIAM1,HUNK,CFAP298
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 74
- Number of somatic mutations (non-coding): 10
- Related genes and loops
- Related gene:
ENSG00000156299,
ENSG00000142149,
ENSG00000265590,
ENSG00000159079,
ENSG00000159082,
- Related loop:
chr21:29050000-29075000~~chr21:32300000-32325000,
chr21:29425000-29450000~~chr21:32275000-32300000,
chr21:31125000-31150000~~chr21:32275000-32300000,
chr21:31850000-31875000~~chr21:32275000-32300000,
chr21:32275000-32300000~~chr21:32550000-32575000,
chr21:32275000-32300000~~chr21:32575000-32600000,
chr21:32275000-32300000~~chr21:32600000-32625000,
chr21:32300000-32325000~~chr21:32450000-32475000,
chr21:32300000-32325000~~chr21:32575000-32600000,
chr21:32300000-32325000~~chr21:32600000-32625000,
chr21:32300000-32325000~~chr21:32725000-32750000,