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Basic information

CohesinDB ID: CDBP00416935

Locus: chr21-32371758-32373234

Data sourse: ENCSR000EFJ, GSE138405, GSE165895, ENCSR000HPG, GSE111913, GSE206145, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE103477, GSE126990, ENCSR330ELC, ENCSR917QNE

Cell type: MDM, RPE, Fibroblast, Hela-Kyoto, Monocytes, A-549, HCAEC, RT-112, IMR-90, K-562, Liver, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.867

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 45%, "5_TxWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, SOX2, XBP1, PATZ1, FOXA1, ZFHX2, INSM2, ZFP64, ZNF362, GLYR1, ZNF189, ZSCAN4, TP63, ZNF629, JMJD1C, MAF, ELF1, KLF6, ETV1, NFE2L2, KLF10, ESR1, MLL, TP73, ZNF561, JUN, CTCF, EP300, ZBTB20, ZNF528, SMC1, KMT2B, PDX1, TFAP2C, CHD8, TOP2A, ZNF317, ZBTB17, ZSCAN21, ZSCAN5A, STAT1, ZBTB48, MLLT3, GATAD1, ERG2, HIC1, HOXC5, ZBTB21, ERG, ASCL1, ETS1, MYC, ZNF2, TSHZ1, RAD21, FOXP2, GRHL3, NKX2-1, GABPA, STAT3, UBN1, RCOR1, ZNF639, NR3C1, CEBPB, ESRRA, ZNF750, KMT2A, CREB1, EZH2, KLF8, FEZF1, GRHL2, SPI1, ZNF664, EHF, IRF1, GATA2, SREBF1, RUNX1, SMC1A, CEBPA, NKX2-2, SIN3A, ZFX, ZNF335, POU4F2, AFF4, SMAD3, PRDM10, ZNF35, RUNX2, CDK6, OSR2, ZNF184, NRF1, ARNT, PBX4, DAXX, ATF2, PRDM9, ZEB2, ZNF518A, HMBOX1, SP2, SUPT5H, FOS, CDK8, SMARCB1, MED1, ZNF558, CEBPD, SCRT2, MYB, KLF16, RBM22, BCL11A, SP1, ASH2L, PRDM6, SMC3, ELL2, ZNF394, NELFA, FOXA2, PAF1, ZNF600, ZNF692, ZSCAN16, WT1, GTF2B, ZNF30, FOXF1, ZNF662, MEF2C, HOXB13, ZKSCAN1, YY1, RELA, JUNB, ZIC2, TAL1, MAX, ZNF143, ZFP69B, KLF4, SP7, NR2F2, KDM5B, TP53, PKNOX1, ZNF334, NFKB1, ELF3, ARRB1, BHLHE40, AR, RXR, ZNF324, ZBTB42, ZNF366, HSF1, BRD4, JUND, MAZ, ZSCAN23, ZNF24, FOSL2

Target gene symbol (double-evidenced CRMs): CFAP298-TCP10L,URB1,SYNJ1,GART,CFAP298,PAXBP1,SON

Function elements

Human SNPs: .

Number of somatic mutations (coding): 22

Number of somatic mutations (non-coding): 18

Related genes and loops

Related gene: ENSG00000142207, ENSG00000265590, ENSG00000159079, ENSG00000159082, ENSG00000159086, ENSG00000159131, ENSG00000159140,

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Deatailed information for cohesin site CDBP00416935