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Basic information

CohesinDB ID: CDBP00416939

Locus: chr21-32381416-32385002

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, ENCSR917QNE, GSE165895, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE152721, GSE206145-NatGen2015, GSE112028, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE145327, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR193NSH, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR807WAC, ENCSR495WGO, ENCSR981FDC, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS

Cell type: MDM, RH4, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, K-562, GM18486, HFFc6, DKO, H1-hESC, SNYDER, GM18505, MB157, GM12878, SK-N-SH, RT-112, HeLa-Tet-On, HAP1, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HUVEC, HCAEC, GM19238, HeLa, OCI-AML-3, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 32% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.622

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 49%, "5_TxWk": 39%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, XBP1, FOXA1, RBFOX2, LEO1, RXRB, MLL4, ZNF28, HDGF, THRB, NFIC, ATF3, ZFP64, CTCFL, PRDM1, GLYR1, ZNF189, PAX5, TP63, SFPQ, CDX2, ZNF467, MYOG, ZNF629, KLF5, TEAD1, ZNF121, RBM39, SNAI2, ESR1, OCA2, TP73, CTCF, TCF12, JUN, BAF155, EP300, MNT, GATA6, PAX8, PRDM4, IRF4, E2F1, SMC1, TEAD4, PDX1, TFAP2C, GLIS1, POU2F2, CHD8, ZSCAN5D, POU5F1, MYCN, TOP2A, RUNX1T1, ZNF778, ZMYND11, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZSCAN21, ZNF205, GATAD1, DDX5, ERG, HOXC5, ASCL1, OGG1, ETS1, MYC, SMARCA4, TOP1, RAD21, GRHL3, RXRA, GABPA, STAT3, APC, SOX10, UBN1, NKX3-1, XRCC5, RCOR1, DNMT3B, ARNTL, NR3C1, CEBPB, ESRRA, CREB1, ZBTB11, EZH2, SPI1, ZNF664, EHF, HDAC2, GATA2, SSRP1, MXI1, SMARCA5, NFIL3, NCOA2, ZIM3, RUNX1, CTNNB1, SMC1A, CEBPA, NKX2-2, SIN3A, ZFX, AFF4, SMAD3, ZNF770, TET2, ZNF654, ERG3, ZNF513, TWIST1, PRDM10, CREBBP, ZNF384, ZBTB2, RUNX2, GATA4, PBX4, NRF1, SOX11, DAXX, ARNT, ZNF48, PRDM9, ZEB2, ATF2, NFIB, PBX3, MAFB, SUPT5H, FOS, MED1, TEAD3, SCRT2, ZMYM3, RBM22, MAFK, NIPBL, SP1, BCL11A, HNF4A, REST, ZNF479, RBM25, ZHX1, ASH2L, HNRNPLL, BCOR, FOXP1, PRDM6, SMC3, STAG1, MLLT1, NFATC3, CBFA2T2, PPARG, FOXA2, PAF1, ZNF600, ZNF692, GTF2B, WT1, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, JUNB, SP140, TCF4, HIF1A, ZIC2, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, GATA1, ZNF143, SPIB, HAND2, SP7, NR2F2, NR2F1, TCF7L2, TP53, ZNF334, MYOD1, ARRB1, ARID4B, PAX3-FOXO1, AR, EGLN2, HSF1, ZBTB26, NCOR1, BRD4, JUND, SCRT1, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): HUNK,GART,PAXBP1,CFAP298,SYNJ1,AP000311.1,URB1,IL10RB,ITSN1,CFAP298-TCP10L,AP000295.1,CRYZL1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 42

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000142149, ENSG00000142207, ENSG00000265590, ENSG00000159079, ENSG00000159082, ENSG00000159086, ENSG00000249624, ENSG00000243646, ENSG00000159131, ENSG00000249209, ENSG00000205758, ENSG00000205726,

eachgene

Deatailed information for cohesin site CDBP00416939