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Basic information

CohesinDB ID: CDBP00416944

Locus: chr21-32392163-32394318

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE126634, ENCSR150EFU, GSE105028, GSE121355, GSE111537, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE152721, GSE51234, GSE120943, ENCSR198ZYJ, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR748MVX, ENCSR767DFK, ENCSR981FDC, GSE62063, ENCSR495WGO, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR944ZCT, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE38411

Cell type: RH4, GM10847, GM2610, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, H9-hESC, B-cell, GM2630, RPE, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, Monocytes, MB157, Lymphoblast, GM12891, GM2588, SK-N-SH, RT-112, HeLa-Tet-On, Macrophage, Ramos, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, OCI-AML-3, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 37% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.489

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "2_TssAFlnk": 35%, "1_TssA": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, MORC2, PAX5, SFPQ, TEAD1, ZNF121, OCA2, MED26, PITX3, HDAC8, ARID5B, E4F1, ZNF75A, SOX5, DEK, E2F4, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, ZMYND11, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, TOP1, FOXK2, UBN1, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, NR2C2, RELB, EP400, RUNX1, HDAC1, CEBPA, NKX2-2, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, ELK1, ZBTB10, TFDP1, ATF2, SP2, SMARCB1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, GSPT2, ARID2, IKZF5, RBM25, MBD2, ELL2, ETV4, NFATC3, MEF2B, CBX3, CREM, CHD2, PAF1, NFATC1, BRF2, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, ILF3, FOSL1, ZNF660, XBP1, KDM4B, PBX2, HNRNPK, THRB, ATF3, ZFP64, WDHD1, CBFB, ZSCAN4, TP63, MITF, MAF, INTS11, JMJD1C, ELF1, ZNF573, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, TAF3, CTCF, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, PDX1, TFAP2C, RBPJ, MLX, ZSCAN21, ZBTB17, ZBTB48, MTA2, ZNF317, NONO, SRF, DDX5, NBN, KDM4A, ZNF2, TSHZ1, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, ZSCAN29, SMARCA5, NFIL3, THAP11, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, BACH1, NFIB, DAXX, ZNF48, PRDM9, ZEB2, NFYA, HMBOX1, ETV6, NCAPH2, PBX3, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAG1, STAG2, MLLT1, ZNF394, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, KAT2B, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, ZNF141, TP53, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, CUX1, ZSCAN23, PGR, FANCL, SOX2, PATZ1, SNAPC4, UBTF, TFAP4, SIN3B, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, KLF1, SOX9, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, KLF12, NKX2-1, GABPA, STAT3, IKZF1, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, ZNF76, NCOA2, ETV5, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, CREBBP, RARA, NFYC, ZNF35, TAF15, ZNF518A, SMAD4, CDK8, CSNK2A1, ZEB1, NCOA1, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF574, TCF7, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, PKNOX1, AR, YAP1, ZNF324, HEXIM1, AHR, DMAP1, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, SFMBT1, ZNF90, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, MLLT3, GATAD1, GMEB2, ARID3A, ZNF300, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, TRPS1, HBP1, TFE3, EHF, IRF1, ZGPAT, MRTFB, ATF1, PTBP1, ZNF45A, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, NMYC, TWIST1, IRF2, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, GR, NRF1, PBX4, NR2C1, SUPT5H, CHD1, FOS, TGIF2, MED1, KDM6B, MYB, CEBPD, ZNF558, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, BRCA1, SP140, ZNF610, HIF1A, OTX2, ZNF519, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): CRYZL1,CFAP298,AP000295.1,IL10RB,GART,PAXBP1,ITSN1,URB1,CFAP298-TCP10L,SYNJ1,AP000311.1,HUNK

Function elements

Human SNPs: .

Number of somatic mutations (coding): 17

Number of somatic mutations (non-coding): 48

Related genes and loops

Related gene: ENSG00000142149, ENSG00000142207, ENSG00000265590, ENSG00000159079, ENSG00000159082, ENSG00000159086, ENSG00000249624, ENSG00000243646, ENSG00000159131, ENSG00000249209, ENSG00000205758, ENSG00000205726,

eachgene

Deatailed information for cohesin site CDBP00416944