- Basic information
- CohesinDB ID: CDBP00417000
- Locus: chr21-32519053-32526591
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE105028, GSE121355, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, GSE106870, GSE94872, GSE118494, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR167MTG, ENCSR000HPG, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, ENCSR000ECS
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Cell type: RH4, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, HeLa-S3, IMR-90, K-562, DKO, HFFc6, H1-hESC, Monocytes, SK-N-SH, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HUVEC, HCAEC, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 22% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.722
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 33%,
"5_TxWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, E2F7, SOX2, NME2, FOXA1, HDGF, ATF3, NFIC, ZFP64, CHD7, MXD4, ZNF189, MITF, ZNF629, MAF, TEAD1, TRIM28, ELF1, NFE2L2, ESR1, OCA2, HNF1B, USF2, CTCF, JUN, TCF12, EP300, ZBTB20, GATA6, DPF2, SOX4, SOX6, E2F1, SMC1, GATAD2A, RBPJ, GLIS1, BRD1, ZSCAN5D, POU5F1, MYCN, CTBP1, ZBTB17, ZBTB48, STAT1, DDX5, TBP, ERG, PAX6, HOXC5, ASCL1, OGG1, ZNF341, ZBTB8A, ETS1, MYC, SMARCA4, ARID1B, RAD21, LHX2, GRHL3, RXRA, PROX1, APC, XRCC5, STAT3, ZNF614, PRDM14, IKZF1, RCOR1, NFE2, NR2F6, ZNF639, VDR, NR3C1, ESRRA, CEBPB, HNRNPL, CREB1, KLF8, GABPB1, SPI1, EHF, KLF17, HDAC2, GATA2, FLI1, MRTFB, ZNF554, ETV5, RUNX1, MAFG, SMC1A, HDAC1, SIRT6, SIN3A, ZFX, NFKBIA, SMAD3, ERG3, SMARCC1, ZBTB2, TAF15, RUNX2, GATA4, GR, ZNF184, PBX4, NRF1, ARNT, HMGB2, ATF2, ZNF48, PRDM9, PBX3, CHD1, FOS, MED1, TEAD3, KDM6B, C11orf30, SETDB1, MAFK, BCL11A, SP1, USF1, REST, ZBTB7A, HNRNPLL, PHIP, PRDM6, AATF, STAG2, STAG1, ZNF394, TRP47, FOXA2, SS18, ZNF600, WT1, ZBTB33, HOXB13, YY1, RELA, JUNB, SP140, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, GFI1B, NR2F2, NR2F1, TP53, ZNF334, BHLHE40, AR, RXR, EGR1, HSF1, RNF2, ZBTB26, BRD4, JUND, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): CFAP298-TCP10L,CFAP298,SYNJ1,EVA1C
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 55
- Related genes and loops