- Basic information
- CohesinDB ID: CDBP00417015
- Locus: chr21-32560770-32563200
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, GSE126634, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE103477, GSE131606, GSE25021, ENCSR000EDW, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, GSE115602, GSE165895, GSE143937, ENCSR000BKV, GSE115250, GSE138405, GSE36578, GSE76893, GSE101921, GSE135093, GSE152721, GSE120943, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, ENCSR879KXD, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR000BTQ, ENCSR167MTG, ENCSR956LGB, GSE110061, GSE129526, ENCSR000HPG, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE64758, GSE131577
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Cell type: MDM, RH4, GM10847, SLK, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, GM12891, GM2588, SK-N-SH, GM19239, HAP1, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HL-60, Hep-G2, A-549, HUVEC, HCAEC, GM19238, BGO3, TC-71, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 32% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.500
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 55%,
"5_TxWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NANOG, SMC1A, FOXA2, POU5F1, CREM, SOX2, ZBTB48, STAT1, SRF, PBX2, YY1, RELA, CHD7, RAD21, ARNT, HIF1A, SMC3, STAT3, MAX, GATA1, NFE2, CBX2, PLAG1, CREB1, STAG1, KDM5B, ESR1, JUN, CTCF, USF1, SP1, BCL11A, GATA6, GATA2, E2F6, ZBTB7A, REST, BRD4, BCOR, SMC1, TEAD4, STAG2, FOSL2
- Target gene symbol (double-evidenced CRMs): MIS18A,EVA1C,SMIM11A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 10
- Related genes and loops
- Related gene:
ENSG00000159055,
ENSG00000166979,
ENSG00000205670,
- Related loop:
chr21:32250000-32275000~~chr21:32550000-32575000,
chr21:32275000-32300000~~chr21:32550000-32575000,
chr21:32400000-32425000~~chr21:32550000-32575000,
chr21:32401983-32404518~~chr21:32561692-32563664,
chr21:32401987-32404521~~chr21:32561668-32563604,
chr21:32402003-32404663~~chr21:32561174-32563689,
chr21:32402043-32404526~~chr21:32561117-32563575,
chr21:32402050-32404562~~chr21:32561335-32563466,
chr21:32402058-32404410~~chr21:32561685-32563661,
chr21:32402099-32404537~~chr21:32561649-32563602,
chr21:32402112-32404476~~chr21:32561642-32563675,
chr21:32402211-32404532~~chr21:32561346-32563661,
chr21:32402351-32404483~~chr21:32561228-32563461,
chr21:32402421-32404494~~chr21:32561489-32563438,
chr21:32402553-32404518~~chr21:32561671-32563639,
chr21:32402573-32404309~~chr21:32561693-32563678,
chr21:32402575-32404404~~chr21:32561712-32563519,
chr21:32412635-32415974~~chr21:32561117-32563575,
chr21:32413356-32415861~~chr21:32561346-32563661,
chr21:32413407-32415950~~chr21:32561489-32563438,
chr21:32413601-32416113~~chr21:32561649-32563602,
chr21:32413701-32415963~~chr21:32561671-32563639,
chr21:32550000-32575000~~chr21:34350000-34375000,