- Basic information
- CohesinDB ID: CDBP00417034
- Locus: chr21-32596424-32597923
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Data sourse: GSE72082, ENCSR000BSB, ENCSR000BLY, GSE25021, GSE131606, ENCSR000EDW, GSE165895, ENCSR000EFJ, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE94872, ENCSR000EEG, ENCSR338DUC, ENCSR000BLS, GSE206145, GSE85526, ENCSR167MTG, GSE129526, ENCSR000HPG, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, ENCSR000ECS
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Cell type: RPE, Fibroblast, HCT-116, Hela-Kyoto, HEKn, Hep-G2, HUVEC, HCAEC, HeLa-S3, IMR-90, SK-N-SH, K-562, HFFc6, HuCC-T1, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 12% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.833
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
-
Chromatin annotation:
"5_TxWk": 57%,
"15_Quies": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: TRP47, CHD8, MYCN, TOP2A, ZFX, WT1, ZBTB48, DUX4, TET2, LEO1, CDK9, RELA, MYC, THAP1, SUPT5H, MED1, NCOA3, CREB1, PHOX2B, MAFK, BCL11A, TBX21, SOX4, REST, IRF4, BRD4, MAZ
- Target gene symbol (double-evidenced CRMs): EVA1C,CFAP298,TIAM1,CFAP298-TCP10L,HUNK,MIS18A,SCAF4,URB1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 12
- Number of somatic mutations (non-coding): 11
- Related genes and loops
- Related gene:
ENSG00000156299,
ENSG00000156304,
ENSG00000142149,
ENSG00000159055,
ENSG00000142207,
ENSG00000166979,
ENSG00000265590,
ENSG00000159079,
- Related loop:
chr21:22775000-22800000~~chr21:32575000-32600000,
chr21:25725000-25750000~~chr21:32600000-32625000,
chr21:31175000-31200000~~chr21:32575000-32600000,
chr21:31700000-31725000~~chr21:32600000-32625000,
chr21:31725000-31750000~~chr21:32575000-32600000,
chr21:31725000-31750000~~chr21:32600000-32625000,
chr21:31780232-31781825~~chr21:32599877-32601833,
chr21:31784993-31787270~~chr21:32596625-32598153,
chr21:31850000-31875000~~chr21:32575000-32600000,
chr21:31850000-31875000~~chr21:32600000-32625000,
chr21:31865248-31867144~~chr21:32598994-32601796,
chr21:31865272-31867342~~chr21:32599933-32601810,
chr21:31865442-31866981~~chr21:32599635-32601835,
chr21:31975000-32000000~~chr21:32600000-32625000,
chr21:32075000-32100000~~chr21:32600000-32625000,
chr21:32095976-32097575~~chr21:32599358-32601801,
chr21:32275000-32300000~~chr21:32575000-32600000,
chr21:32275000-32300000~~chr21:32600000-32625000,
chr21:32277555-32280325~~chr21:32599877-32601833,
chr21:32277665-32280330~~chr21:32599933-32601810,
chr21:32300000-32325000~~chr21:32575000-32600000,
chr21:32300000-32325000~~chr21:32600000-32625000,
chr21:32305431-32307333~~chr21:32600164-32601910,
chr21:32350000-32375000~~chr21:32600000-32625000,
chr21:32359189-32360657~~chr21:32599840-32601900,
chr21:32375000-32400000~~chr21:32575000-32600000,
chr21:32375000-32400000~~chr21:32600000-32625000,
chr21:32383323-32384788~~chr21:32600164-32601910,
chr21:32385843-32387035~~chr21:32599838-32601801,
chr21:32391754-32394231~~chr21:32599840-32601943,
chr21:32391823-32394318~~chr21:32599840-32601900,
chr21:32391849-32394127~~chr21:32599840-32601796,
chr21:32400000-32425000~~chr21:32575000-32600000,
chr21:32400000-32425000~~chr21:32600000-32625000,
chr21:32401983-32404518~~chr21:32600164-32601910,
chr21:32401987-32404521~~chr21:32599840-32601943,
chr21:32402041-32404495~~chr21:32599358-32601801,
chr21:32402043-32404526~~chr21:32599739-32601803,
chr21:32402099-32404537~~chr21:32599842-32601842,
chr21:32402110-32404433~~chr21:32599840-32601900,
chr21:32402112-32404476~~chr21:32599933-32601810,
chr21:32402135-32404476~~chr21:32598994-32601796,
chr21:32402183-32404544~~chr21:32600127-32601810,
chr21:32402211-32404532~~chr21:32599851-32601933,
chr21:32402220-32404493~~chr21:32600085-32601819,
chr21:32402351-32404483~~chr21:32599809-32601807,
chr21:32402421-32404494~~chr21:32599840-32601796,
chr21:32402474-32404277~~chr21:32599132-32601791,
chr21:32402478-32404275~~chr21:32599877-32601833,
chr21:32402531-32404281~~chr21:32600444-32601827,
chr21:32402537-32404397~~chr21:32599838-32601801,
chr21:32402544-32404481~~chr21:32599871-32601809,
chr21:32402553-32404518~~chr21:32599805-32601899,
chr21:32402562-32404219~~chr21:32600440-32601787,
chr21:32402573-32404309~~chr21:32599384-32601896,
chr21:32402578-32404394~~chr21:32599082-32601833,
chr21:32402579-32404271~~chr21:32600154-32601803,
chr21:32402590-32404484~~chr21:32599845-32601920,
chr21:32402599-32404105~~chr21:32599635-32601835,
chr21:32402611-32404103~~chr21:32600122-32601828,
chr21:32402633-32404158~~chr21:32600087-32601774,
chr21:32402649-32404059~~chr21:32600348-32601794,
chr21:32402698-32403972~~chr21:32600504-32601777,
chr21:32412413-32413787~~chr21:32599845-32601920,
chr21:32412745-32415761~~chr21:32598994-32601796,
chr21:32413259-32415823~~chr21:32599838-32601801,
chr21:32413356-32415861~~chr21:32599851-32601933,
chr21:32413407-32415950~~chr21:32599840-32601796,
chr21:32413601-32416113~~chr21:32599842-32601842,
chr21:32413701-32415963~~chr21:32599805-32601899,
chr21:32413909-32415933~~chr21:32599809-32601807,
chr21:32413950-32415829~~chr21:32600085-32601819,
chr21:32450000-32475000~~chr21:32575000-32600000,
chr21:32475000-32500000~~chr21:32575000-32600000,
chr21:32500000-32525000~~chr21:32600000-32625000,
chr21:32600000-32625000~~chr21:32725000-32750000,