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Basic information

CohesinDB ID: CDBP00417035

Locus: chr21-32598775-32602954

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, T-47D, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 80% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.133

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 48%, "5_TxWk": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, ZNF660, XBP1, FOXA1, RBFOX2, LEO1, RXRB, MLL4, PBX2, KDM3A, TFAP4, ATF3, THRB, HNRNPUL1, ZNF362, RUNX3, ATF4, CBFB, MXD4, ZNF189, PAX5, TP63, MITF, CDX2, ZNF467, ZNF629, JMJD1C, TEAD1, RBM39, NFE2L2, LMO2, ESR1, OCA2, TP73, JUN, CTCF, TCF12, EP300, KLF1, L3MBTL4, SOX5, IRF4, RFX5, SOX6, DEK, E2F1, ZNF528, SMC1, TEAD4, FOXA3, GATAD2A, GTF2F1, RBPJ, GLIS1, POU2F2, CHD8, ZNF425, POU5F1, ZNF263, MYCN, RUNX1T1, ZMYND11, ZBTB17, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ARID3A, ERG2, ERG, HOXC5, ETS1, ONECUT1, MYC, SMARCA4, TSHZ1, HOMEZ, RAD21, ZNF2, GRHL3, RXRA, PROX1, NKX2-1, GABPA, XRCC5, ZNF614, NKX3-1, PRDM14, RCOR1, MIER3, ZNF639, NR2F6, NFE2, DNMT3B, NR3C1, HNRNPL, STAT5B, CREB1, EZH2, TBL1XR1, JMJD6, FEZF1, ZNF652, ZHX2, SPI1, MIXL1, TFE3, KDM5A, IRF1, HDAC2, GATA2, ZNF644, MXD3, SIX2, DRAP1, ZGPAT, SMARCA5, MRTFB, NFIL3, ETV5, CC2D1A, RUNX1, THAP11, SMC1A, BCL6, CEBPA, NKX2-2, LDB1, FIP1L1, ZFX, SOX13, AFF4, ZNF335, SMAD3, TET2, ERG3, ZNF654, TRIM22, ZNF18, PRDM10, RARA, ZNF384, CREBBP, ZBTB2, ZNF35, RUNX2, OSR2, PBX4, ARNT, ZNF48, SMAD4, PBX3, SUPT5H, CDK8, HMGXB4, MED1, TEAD3, ZEB1, ZXDB, PIAS1, SMAD1, NCOA1, KLF16, RBM22, MAFK, SP1, BCL11A, GSPT2, HNF4A, NR4A1, IKZF5, REST, ZHX1, BCOR, FOXP1, PRDM6, SMC3, STAG1, STAG2, ZNF394, TRP47, CBFA2T2, PPARG, TBL1X, FOXA2, CREM, CHD2, PAF1, CBX3, ZNF600, ZNF692, ZNF316, WT1, MAFF, RBBP5, ZNF574, MEF2C, CDK9, ZNF580, HOXB13, MPHOSPH8, KDM1A, YY1, RELA, SP140, ZIC2, HIF1A, SKIL, BATF, MAX, ZNF143, AGO2, GATA1, CEBPG, SP7, NR2F2, TCF7L2, KDM5B, TP53, PKNOX1, ZNF334, BRD2, ELF3, KAT8, ARID4B, AR, NFKBIZ, BHLHE40, ZNF324, ZNF366, RB1, ZBTB26, MYNN, IKZF2, BRD4, JUND, ILF3, MAZ, BRCA1, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): MIS18A,PAXBP1,SYNJ1,HUNK,TIAM1,CFAP298,SCAF4,CFAP298-TCP10L,URB1,EVA1C

Function elements

Human SNPs: .

Number of somatic mutations (coding): 177

Number of somatic mutations (non-coding): 63

Related genes and loops

Related gene: ENSG00000156299, ENSG00000156304, ENSG00000142149, ENSG00000159055, ENSG00000142207, ENSG00000166979, ENSG00000265590, ENSG00000159079, ENSG00000159082, ENSG00000159086,

eachgene

Deatailed information for cohesin site CDBP00417035