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Basic information

CohesinDB ID: CDBP00417038

Locus: chr21-32610128-32610562

Data sourse: GSE206145, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, RPE

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 57%, "7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, ZBTB44, MORC2, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, ZNF75A, SOX5, ZNF407, E2F4, DEK, ZNF674, ZNF410, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, ZNF263, BRD3, POU5F1, CTBP1, ZMYND11, ERF, DUX4, STAT1, ZNF563, SAP130, ERG, ZBTB21, ZNF597, ZBTB8A, NFKB2, EZH1, SMARCA4, RFX1, TOP1, FOXK2, ZNF8, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, DACH1, CEBPB, HNRNPL, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, DRAP1, ZNF785, NR2C2, RELB, EP400, RUVBL2, RUNX1, HDAC1, CEBPA, NKX2-2, ZNF707, IRF3, PALB2, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZXDC, ZBTB2, ELK1, ZBTB10, TFDP1, ATF2, SATB1, FOXM1, FOXJ2, SP2, SMARCB1, GMEB1, TERF1, PML, ZNF331, SMAD1, PIAS1, C11orf30, EVI1, MBD1, STAT5A, GSPT2, IKZF5, ARID2, OVOL3, ZSCAN31, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, NFATC1, PAF1, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, PLAG1, ZFP69B, BCL11B, KLF4, ZNF281, ZNF784, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ZNF316, FOSL1, SMARCA2, ZNF660, XBP1, KDM4B, ZNF101, PBX2, ZNF596, TSC22D4, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, ZNF273, TP63, ZSCAN4, MITF, ZNF467, INTS11, JMJD1C, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, ZNF624, FUS, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF423, ZNF350, ZNF280A, PDX1, RBPJ, TFAP2C, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, ZNF317, NONO, SRF, DDX5, NBN, CHD4, ZNF329, PBX1, ZNF626, KDM4A, ZNF2, FOXP2, HOMEZ, TSHZ1, RXRA, NKX3-1, PRDM14, MIER3, TERF2, HNRNPH1, LEF1, VDR, TEAD2, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, ZNF669, KLF8, GRHL2, ZNF565, EBF3, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, LDB1, AFF4, SOX13, POU4F2, ZNF770, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, BACH1, NFIB, ZNF48, ZEB2, NFYA, ETV6, NCAPH2, ZNF10, PBX3, HMGXB4, MAFB, TEAD3, DIDO1, ZXDB, ZNF680, U2AF1, TAF7, KLF9, ZBTB18, ZNF41, TBX5, USF1, BCL11A, SP1, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, MAFF, ESR2, ZNF580, ZKSCAN1, KLF7, KDM1A, BCL3, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, ZNF143, AGO2, MTA1, CBX2, ZNF768, TP53, NFKB1, ZSCAN22, BRD2, PHF5A, KAT8, ARRB1, TBX21, ZFP41, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, PGR, FANCL, CBX5, SOX2, PATZ1, SNAPC4, UBTF, SMAD1-5, TFAP4, SIN3B, BMI1, SETX, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, SND1, KLF1, ZNF695, SOX9, ZNF260, SOX4, E2F6, TRIM24, RFX5, U2AF2, GTF2F1, GLIS1, POU2F2, ZNF778, KDM4C, ZBTB1, ASH1L, ZSCAN5A, ELK4, ERG2, SP4, TBP, HOXC5, OGG1, ETS1, MYC, ARID1B, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, TAF9B, ZNF490, ZNF76, NFYB, ZNF554, NCOA2, ETV5, GTF2A2, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, MEF2A, RARA, CREBBP, ZNF35, ZNF384, TAF15, NFYC, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, SPDEF, NCOA1, GTF3C2, ZNF22, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, ZNF34, CXXC4, ZNF816, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, YY2, FOXO3, RELA, TARDBP, SKIL, MAX, GFI1B, NEUROG2, NR2F1, KDM5B, TCF7L2, PKNOX1, MYOD1, T, AR, KMT2D, PAX3-FOXO1, YAP1, ZNF324, HEXIM1, ZNF280D, DMAP1, AHR, FOSL2, ZNF391, HMG20A, ZSCAN5C, E2F7, HMGN3, SUZ12, RBFOX2, ZNF28, ZFHX2, SFMBT1, LYL1, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, COBLL1, RCOR2, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, SRC, RUNX1T1, ID3, CDK7, GATAD1, GMEB2, ARID3A, ZNF585B, ASCL1, MIER1, ZNF341, USP7, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, ZNF667, ZNF639, TCF25, ZNF750, ZNF501, ZNF85, JMJD6, FEZF1, HBP1, TFE3, ZNF664, IRF1, EHF, SREBF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, ZNF45A, SMC1A, MAFG, CBX1, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, NMYC, TWIST1, IRF2, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, NRF1, NR2C1, CHD1, SUPT5H, FOS, TGIF2, MED1, RFX2, KDM6B, MYB, SCRT2, CEBPD, ZNF558, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, PHIP, TCF3, TAF2, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF740, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF837, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZNF846, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): CFAP298-TCP10L,EVA1C,URB1,SCAF4,HUNK,MIS18A,SYNJ1,CFAP298,PAXBP1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 9

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000156304, ENSG00000142149, ENSG00000159055, ENSG00000142207, ENSG00000166979, ENSG00000265590, ENSG00000159079, ENSG00000159082, ENSG00000159086,

eachgene

Deatailed information for cohesin site CDBP00417038