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Basic information

CohesinDB ID: CDBP00417082

Locus: chr21-32769734-32773333

Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE64758, GSE131577, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE80989, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE62063, ENCSR807WAC, ENCSR981FDC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM2610, SLK, GM19240, OCI-AML-3, HSPC, Liver, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, Ishikawa, VU1199-F, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, HAP1, Macrophage, Ramos, MCF-7, GM12892, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 51% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.289

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,ESCO2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "2_TssAFlnk": 32%, "1_TssA": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF426, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, ZNF212, ZNF23, PITX3, HDAC8, ZNF561, ZNF577, ARID5B, E4F1, ZNF157, SOX5, PYGO2, ZNF407, E2F4, DEK, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, XRCC3, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, ERF, ZMYND11, STAT1, ZNF488, ZNF134, SAP130, ERG, ZBTB21, ZNF597, ZBTB8A, SMARCA4, RFX1, FOXK2, ZNF8, ZNF398, RCOR1, NR2F6, CD74, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, ELF4, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, NR2C2, HCFC1, ZNF785, RELB, EP400, RUNX1, HDAC1, CEBPA, ZNF707, REPIN1, ZNF654, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZXDC, ZBTB2, ELK1, ZBTB10, TFDP1, ATF2, SNIP1, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, ZNF331, SMAD1, C11orf30, EVI1, MBD1, STAT5A, IKZF5, ARID2, OVOL3, RBM25, ZSCAN31, AFF1, MBD2, HMGB1, ETV4, NFATC3, ZSCAN18, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZNF510, ZFP36, TCF4, ZNF417, BATF, MAF1, PLAG1, ZFP69B, BCL11B, ZNF784, ZNF281, IRF5, ZBTB6, MED, BCL6B, EGR2, RBM14, ELF3, ARID4B, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, HNF1A, ZNF101, KDM4B, PBX2, ZNF596, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, ZSCAN4, TP63, MITF, ZNF467, INTS11, MAF, ELF1, RBM39, KLF10, SMAD5, ZNF624, ZBTB49, FUS, CTCF, JUN, L3MBTL4, ZBTB20, MNT, LMO1, RYBP, DPF2, SIX5, IRF4, ZNF423, DDX20, ZNF776, ZNF350, ZNF280A, PDX1, RBPJ, TFAP2C, MLX, YBX1, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, ZNF317, NONO, SRF, NBN, CHD4, PBX1, ZNF329, ZNF626, TSHZ1, KDM4A, ZNF2, FOXP2, HOMEZ, RXRA, MIER3, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, CCAR2, TBL1XR1, ZNF669, KLF8, ARHGAP35, GRHL2, EBF3, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, LDB1, EZH2phosphoT487, AFF4, SOX13, ZNF747, ZFP3, ZNF770, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, BACH1, ZNF48, ZEB2, HMBOX1, PBX3, NCAPH2, ZNF10, ETV6, HMGXB4, TEAD3, DIDO1, ZXDB, ZNF680, U2AF1, TAF7, KLF9, ZBTB18, TBX5, USF1, BCL11A, SP1, NKX2-5, ZNF479, ATF7, SALL4, ASH2L, ZNF548, CTBP2, PRDM6, ZNF623, SMC3, MLLT1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KLF7, KDM1A, ZNF19, BCL3, ZNF441, KAT2B, ZNF266, BRG1, ZNF155, ZNF830, ZIC2, PCGF1, GATA3, KLF15, TAL1, ZNF143, AGO2, MTA1, TP53, ZNF645, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, TBX21, ZFP41, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, SPIN1, JUND, CUX1, ZSCAN23, IRF9, TBX2, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, RING1B, TFAP4, SIN3B, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, KLF1, ZNF695, ZNF260, SOX4, E2F6, TRIM24, RFX5, U2AF2, GTF2F1, GLIS1, CDK9-HEXIM1, POU2F2, ZSCAN5D, ZNF778, ZBTB1, ASH1L, ZSCAN5A, ELK4, ZMYND8, ERG2, SP4, TBP, HOXC5, OGG1, ETS1, MYC, ARID1B, ZNF24, PHF21A, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, ZNF343, INO80, DNMT3B, SRSF3, EZH2, ZNF514, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, TAF9B, ZNF777, ZNF76, ZNF554, ETV5, GTF2A2, AHRR, BCL6, SIN3A, ZBTB12, ZFP37, ZNF16, ERG3, MEF2A, MYBL2, RARA, CREBBP, NFYC, ZNF35, TAF15, ZNF169, ZNF384, HMGB2, SMAD4, ZNF518A, CBFA2T3, ZEB1, ZNF264, ZNF250, NCOA1, SREBF2, ZNF22, RBM22, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, ZNF34, PPARG, HDAC6, ZNF44, ZNF692, GTF2B, ZNF30, ZNF174, JDP2, ZNF574, ZNF662, TCF7, YY2, ZNF318, RELA, TARDBP, CHAMP1, ZNF282, SKIL, MGA, MAX, ZNF223, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, ZNF791, NEUROG2, PKNOX1, MYOD1, AR, KMT2D, ZBTB16, ZNF324, RBAK, HEXIM1, ZNF280D, ZZZ3, DMAP1, AHR, FOSL2, ZNF391, HMG20A, E2F7, ZSCAN5C, HMGN3, MEIS2, RBFOX2, ZFHX2, ZNF529, ZNF274, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, HDAC3, ZNF629, KLF5, THRAP3, BCLAF1, TRIM28, ZNF26, ETV1, RCOR2, USF2, ZFP91, TCF12, BAF155, EP300, ZNF302, PRDM4, GLI4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, BRD1, MYCN, RUNX1T1, ID3, MLLT3, GATAD1, GMEB2, ARID3A, MIER1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, TCF25, ZNF639, ZNF501, ZNF93, ZNF416, FEZF1, TRPS1, HES1, HBP1, TFE3, EHF, ZNF664, IRF1, ZGPAT, ZNF766, MRTFB, MYF5, ATF1, PTBP1, CBX1, SMC1A, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, NMYC, TWIST1, IRF2, NCOA6, PRPF4, ZNF701, BRD9, ZSCAN30, GATA4, OSR2, ZNF184, NRF1, PBX4, NR2C1, SUPT5H, CHD1, FOS, TGIF2, MED1, ZNF558, CEBPD, SCRT2, MYB, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, GLI2, CCNT2, POU2F3, PHIP, TCF3, SALL1, ZNF783, SKI, NELFA, ZNF283, NCOA4, KLF13, PAX7, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF610, SP140, HIF1A, OTX2, ZNF449, GATA1, HAND2, CEBPG, SP7, NR2F2, ZNF354C, ZNF687, ZNF213, ZNF837, ZNF843, BHLHE40, NFKBIZ, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF304, MEF2D, BRCA1

Target gene symbol (double-evidenced CRMs): SYNJ1,SON,DONSON,URB1,GART,PAXBP1,SCAF4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 124

Number of somatic mutations (non-coding): 83

Related genes and loops

Related gene: ENSG00000156304, ENSG00000142207, ENSG00000159082, ENSG00000159086, ENSG00000159131, ENSG00000159140, ENSG00000159147,

eachgene

Deatailed information for cohesin site CDBP00417082