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Basic information

CohesinDB ID: CDBP00417104

Locus: chr21-32844499-32845578

Data sourse: ENCSR000BLD, GSE131606, GSE72082, GSE138405, GSE110061, GSE116344, GSE129526, GSE206145-NatGen2015, ENCSR000EDE, GSE68388, ENCSR703TNG, GSE126990, GSE108869, ENCSR000ECS

Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, Hela-Kyoto, RH4, HeLa-S3, HuCC-T1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 44%, "15_Quies": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, ZNF391, ZSCAN5C, ZNF660, MEIS2, XBP1, PATZ1, FOXA1, PBX2, MLL4, TFAP4, INSM2, ATF3, ZFP64, ZNF362, ZBTB44, PRDM1, CHD7, KLF14, ZNF189, ZSCAN4, TP63, ZNF629, JMJD1C, MAF, MYOG, TRIM28, ZNF121, TEAD1, KLF10, ESR1, OCA2, JUN, CTCF, BAF155, KLF1, ZNF695, GATA6, PAX8, ZNF528, ZNF280A, TEAD4, PDX1, TFAP2C, GLIS1, NANOG, CHD8, ID3, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, ZSCAN21, SRF, ZNF134, HIC1, TBP, ERG, ZBTB21, ASCL1, MYC, ZNF2, TSHZ1, RAD21, GRHL3, PROX1, NKX2-1, GABPA, STAT3, NKX3-1, ZNF398, RCOR1, ZNF639, DACH1, ARNTL, NR3C1, CEBPB, ZNF750, CREB1, EZH2, KLF8, FEZF1, SPI1, KLF17, HDAC2, GATA2, FLI1, ZNF766, MRTFB, ZNF554, RUNX1, CEBPA, NKX2-2, EZH2phosphoT487, ZNF335, ZFX, SMAD3, ZNF770, SMARCC1, PRDM10, ZNF35, RUNX2, CDK6, GATA4, OSR2, ZNF184, SP3, PBX4, ZBTB10, ATF2, PRDM9, ZEB2, ZNF518A, MAFB, ZNF10, FOS, CDK8, SP2, SMARCB1, MED1, ZEB1, ZXDB, ZNF558, SCRT2, PIAS1, CEBPD, MYB, KLF16, MAFK, HNF4A, ATF7, PHIP, GLIS2, PRDM6, SMC3, ELL2, ZNF394, SKI, FOXA2, ZNF600, ZNF692, ZSCAN16, ZNF30, WT1, MAFF, ZNF574, MEF2C, ZNF662, CDK9, HOXB13, ZNF580, KDM1A, YY1, RELA, JUNB, HIF1A, OTX2, TAL1, MAX, ZNF143, CEBPG, ZFP69B, SP7, GFI1B, TCF7L2, TP53, PKNOX1, BCL6B, NFKB1, ZSCAN22, MYOD1, BRD2, ZNF843, PAX3-FOXO1, AR, ZNF324, ZNF366, ZBTB42, MYNN, JUND, BRD4, ZSCAN23, ZNF24, FOSL2

Target gene symbol (double-evidenced CRMs): ITSN1,IL10RB,SYNJ1,AP000311.1,EVA1C,AP000295.1,SMIM11A,CRYZL1,IFNAR1,ATP5PO,TMEM50B,IFNGR2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 7

Related genes and loops

Related gene: ENSG00000166979, ENSG00000159082, ENSG00000249624, ENSG00000243646, ENSG00000142166, ENSG00000159128, ENSG00000142188, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000205670,

eachgene

Deatailed information for cohesin site CDBP00417104