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Basic information

CohesinDB ID: CDBP00417168

Locus: chr21-33018853-33032029

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BSB, GSE126634, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE131606, GSE25021, GSE143937, GSE67783, ENCSR000BKV, GSE122299, GSE86191, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE130135, GSE116344, GSE106870, GSE145327, GSE94872, GSE118494, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE97394, GSE55407, ENCSR167MTG, GSE131956, GSE110061, GSE129526, GSE111913, ENCSR153HNT, GSE83726, GSE50893, GSE126755, GSE131577

Cell type: RH4, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, B-cell, H9-hESC, GM2630, RPE, Fibroblast, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, Monocytes, MB157, GM12891, GM2588, GBM39, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, HUES64, Macrophage, MCF-7, THP-1, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, HUVEC, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 22% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.500

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "13_ReprPC": 33%, "12_EnhBiv": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, FOXA1, KDM3A, ZNF322, IKZF3, MORC2, TEAD1, ZNF121, OCA2, MED26, HDAC8, ZNF561, ZNF577, E4F1, ZNF528, KMT2B, JARID2, NANOG, POU5F1, ZNF263, TOP2A, BRD3, CTBP1, STAT1, ERG, ZBTB21, ZBTB8A, SMARCA4, ZNF398, RCOR1, CEBPB, CREB1, BMPR1A, GABPB1, ZHX2, ZNF257, KLF17, GATA2, MXD3, SIX2, FLI1, MXI1, ZNF785, HCFC1R1, RUNX1, CEBPA, TET2, ZNF654, SMARCC1, PRDM10, SOX11, ZBTB10, ATF2, FOXM1, SP2, SMAD1, EVI1, IKZF5, RBM25, ZNF605, MBD2, CBFA2T2, CBX3, CHD2, SS18, ZSCAN16, WT1, MEF2C, NEUROD1, MCM3, MAF1, PLAG1, ZFP69B, KLF4, ZNF281, ZBTB6, EGR2, RBM14, RXR, ZNF366, HSF1, ZBTB26, SCRT1, FOSL1, ZNF660, XBP1, ZNF101, PBX2, ZNF596, ATF3, ZFP64, CBFB, ZNF273, TP63, MITF, ZNF467, JMJD1C, INTS11, ELF1, ZNF573, SNAI2, KLF10, CTCF, JUN, ZBTB20, MNT, RYBP, IRF4, ZNF423, ZNF280A, PDX1, TFAP2C, RBPJ, MTA2, ZBTB17, ZBTB48, ZSCAN21, ZNF317, DDX5, KDM4A, ZNF2, FOXP2, PRDM14, NR3C1, ESRRA, KMT2A, ZBTB11, KLF8, ZKSCAN5, ZBTB14, EZH2phosphoT487, LDB1, SP3, ARNT, BACH1, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, ZNF10, ZXDB, KLF9, USF1, BCL11A, SP1, ZNF479, ASH2L, PCGF2, CTBP2, GLIS2, SMC3, STAG1, ZNF394, TRP47, AGO1, MTA3, MEIS1, ZNF580, BCL3, KDM1A, ZNF441, BRG1, ZIC2, PCGF1, KLF15, TAL1, ZNF143, CBX2, TP53, ZNF334, ZSCAN22, ZNF140, BRD2, EGR1, TFIIIC, RNF2, BRD4, JUND, ZSCAN23, ZNF468, PGR, SOX2, PATZ1, RING1B, CHD7, ZNF189, MZF1, ESR1, ZNF524, KLF1, ZNF695, E2F6, TRIM24, ZNF92, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZBTB1, ZSCAN5A, ERG2, SP4, HIC1, TBP, OGG1, ETS1, MYC, KLF12, GABPA, STAT3, INO80, EZH2, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, ZNF777, ZNF76, NFYB, ZNF554, BCL6, SIN3A, ZBTB12, ERG3, CREBBP, ZNF35, ZNF384, TAF15, ZNF518A, CDK8, ZEB1, ZMYM3, ZNF22, HNF4A, REST, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, TBL1X, HDAC6, ZNF692, ZNF30, ZNF574, ZNF662, RELA, TARDBP, MAX, NR2F1, TCF7L2, KDM5B, MYOD1, PAX3-FOXO1, ZNF445, AR, ZNF324, HEXIM1, AHR, FOSL2, ZNF391, HMGN3, MEIS2, SUZ12, ZNF28, ZFHX2, ZNF90, INSM2, ZNF362, CTCFL, KLF14, ZNF736, ZNF629, ZNF506, KLF5, TRIM28, ETV1, USF2, TCF12, EP300, E2F1, SMC1, TEAD4, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, ZNF649, ZNF341, RAD21, GRHL3, XRCC5, ZNF639, PTBP1, SMC1A, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, CBX8, SMAD2, ZSCAN30, OSR2, ZNF184, NRF1, CHD1, MED1, KDM6B, MYB, SCRT2, ZNF558, ZNF3, L3MBTL2, KLF16, ZBTB7A, PHIP, TCF3, SKI, ZNF283, FOXA2, RBBP5, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ZNF610, SP140, HIF1A, OTX2, ZNF519, ZNF449, GATA1, SP7, ZNF843, BHLHE40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): EVA1C,IFNAR1,TMEM50B,IFNGR2

Function elements

Human SNPs: Lateral_ventricle_volume

Number of somatic mutations (coding): 434

Number of somatic mutations (non-coding): 210

Related genes and loops

Related gene: ENSG00000166979, ENSG00000142166, ENSG00000159128, ENSG00000142188,

eachgene

Deatailed information for cohesin site CDBP00417168