- Basic information
- CohesinDB ID: CDBP00417173
- Locus: chr21-33042060-33043831
-
Data sourse: ENCSR000EFJ, GSE86191, GSE129526, GSE111913, ENCSR000BLY, GSE206145, GSE101921, GSE206145-NatGen2015, GSE68388, GSE83726, GSE116344, ENCSR000ECS, GSE165895
-
Cell type: RPE, Fibroblast, HCT-116, RH4, HCAEC, HeLa-S3, IMR-90, SK-N-SH, RT-112, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: NIPBL,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
93% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"14_ReprPCWk": 47%,
"13_ReprPC": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOSL1, ZNF660, XBP1, FOXA1, SUZ12, MLL4, TFAP4, ATF3, NFIC, CHD7, ZNF629, TEAD1, SNAI2, ESR1, OCA2, JUN, CTCF, TCF12, EP300, PAX8, SOX4, E2F1, SMC1, TEAD4, CHD8, ZSCAN5D, MYCN, BRD3, TOP2A, ZBTB17, ZBTB48, ERG, ZBTB21, HOXC5, NFKB2, MYC, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, STAT3, VDR, ARNTL, NR3C1, CEBPB, CREB1, EZH2, ZHX2, SPI1, EHF, GATA2, FLI1, MRTFB, NCOA2, ATF1, SIN3A, ZFX, SMAD3, ZBTB12, ERG3, SMARCC1, PRDM10, ZNF35, RUNX2, SMAD2, GATA4, ZNF184, ARNT, PBX4, SOX11, DAXX, ATF2, HMGB2, SMAD4, ZEB2, PBX3, FOS, CDK8, MED1, ZXDB, ZNF558, SCRT2, USF1, REST, PHIP, SMC3, NCOR2, STAG2, ZNF394, CHD2, ZNF600, ZNF692, WT1, YY1, RELA, JUNB, SP140, ZIC2, OTX2, GATA3, TAL1, MAX, GATA1, ZNF143, KLF4, TCF7L2, TP53, ZNF334, BRD2, AR, TAF1, NOTCH3, BRD4, JUND, SCRT1, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): EVA1C,IFNAR1,IFNGR2,TMEM50B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000166979,
ENSG00000142166,
ENSG00000159128,
ENSG00000142188,
- Related loop:
chr21:32500000-32525000~~chr21:33025000-33050000,
chr21:32925000-32950000~~chr21:33025000-33050000,
chr21:33025000-33050000~~chr21:33125000-33150000,
chr21:33025000-33050000~~chr21:33325000-33350000,
chr21:33025000-33050000~~chr21:33375000-33400000,
chr21:33025000-33050000~~chr21:33425000-33450000,
chr21:33025000-33050000~~chr21:33450000-33475000,
chr21:33025000-33050000~~chr21:36675000-36700000,
chr21:33025000-33050000~~chr21:36700000-36725000,