- Basic information
- CohesinDB ID: CDBP00417185
- Locus: chr21-33067051-33068063
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Data sourse: GSE67783, GSE86191, GSE98367, GSE206145, GSE62063, GSE120943, ENCSR153HNT, GSE83726, GSE55407
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Cell type: RPE, HCT-116, Monocytes, RH4, THP-1, K-562, HSPC, Macrophage, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: NIPBL,SA1,Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
93% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"13_ReprPC": 59%,
"14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, MLL4, HDGF, THAP1, ZBTB44, MORC2, PAX5, ZNF320, TEAD1, ZNF121, LMO2, MED26, ZNF561, E2F4, ZNF528, KMT2B, JARID2, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, ERF, DUX4, STAT1, ERG, ZBTB21, ZBTB8A, NFKB2, EZH1, SMARCA4, FOXK2, ZNF8, ZNF398, RCOR1, DACH1, CEBPB, CREB1, GABPB1, ZHX2, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, MXI1, RELB, HCFC1R1, RUNX1, CEBPA, HDAC1, NKX2-2, TET2, TRIM22, SMARCC1, PRDM10, ZBTB2, ELK1, ZBTB10, TFDP1, ATF2, FOXM1, SP2, SMARCB1, TERF1, C11orf30, EVI1, STAT5A, RBM25, MBD2, ZNF704, HMGB1, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, SS18, WT1, MEF2C, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, ZFP69B, BCL11B, KLF4, MED, EGR2, RBM14, ELF3, RXR, EGLN2, ZNF366, HSF1, ZBTB26, SCRT1, ILF3, FOSL1, ZNF660, XBP1, HNF1A, ZNF101, PBX2, HNRNPK, ATF3, ZC3H8, ZFP64, RUNX3, CBFB, ZNF273, TP63, ZSCAN4, MITF, BACH2, ZNF467, JMJD1C, MYOG, INTS11, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, ZBTB20, MNT, RYBP, DPF2, IRF4, ZNF423, ZNF350, PDX1, TFAP2C, RBPJ, ZNF317, ZBTB17, ZBTB48, ZSCAN21, MTA2, DDX5, NBN, PBX1, KDM4A, ZNF2, FOXP2, TSHZ1, BATF3, NKX3-1, PRDM14, TERF2, VDR, NR3C1, KMT2A, KLF8, GRHL2, ZBTB14, ZNF146, SMARCA5, CTNNB1, ZBTB24, EZH2phosphoT487, LDB1, ZNF770, ZNF513, SP3, ARNT, BACH1, DAXX, PRDM9, ZEB2, HMBOX1, ETV6, NCAPH2, ZNF10, PBX3, ZXDB, U2AF1, KLF9, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, PCGF2, CTBP2, GLIS2, ZNF623, SMC3, STAG1, MLLT1, ZNF394, TRP47, MTA3, EBF1, MEIS1, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, CBX2, ZNF141, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, ZSCAN23, PGR, SOX2, PATZ1, RING1B, TFAP4, BMI1, CHD7, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, TP73, KLF1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5A, HIC1, SP4, ERG2, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, ZNF24, KLF12, NKX2-1, GABPA, STAT3, IKZF1, INO80, SRSF3, EZH2, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, ZNF554, BCL6, SIN3A, ZFP37, ERG3, MEF2A, RARA, ZNF384, ZNF35, CREBBP, TAF15, ZNF518A, CBFA2T3, CDK8, ZEB1, ZMYM3, MAFK, NR4A1, REST, ARID1A, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, TBL1X, ZNF716, HDAC6, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, RELA, TARDBP, ZNF611, SKIL, MAX, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, T, AR, PAX3-FOXO1, ZBTB16, ZNF324, HEXIM1, AHR, FOSL2, ZNF391, HMG20A, ZSCAN5C, MEIS2, SUZ12, ZFHX2, LYL1, ZNF90, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, ZNF736, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, MLL, HNF1B, TCF12, EP300, BAF155, SOX6, RAD51, E2F1, SMC1, TEAD4, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, ARID3A, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, NFE2, ZNF639, ZNF750, FEZF1, ZNF664, IRF1, HEXIM1-CDK9, ZIM3, ATF1, SMC1A, MAFG, SIRT6, ZNF335, ZFX, SMAD3, PCBP2, CBX8, NOTCH1, RUNX2, CDK6, ZSCAN30, OSR2, ZNF184, NRF1, PBX4, CHD1, FOS, MED1, KDM6B, MYB, SCRT2, ZNF558, VEZF1, L3MBTL2, KLF16, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, FOXA2, RBBP5, ZNF600, ZBED1, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, ZNF519, ZNF449, GATA1, TLE3, SP7, NCOA3, NR2F2, BHLHE40, ZBTB42, MYNN, CLOCK, MAZ, BRCA1
- Target gene symbol (double-evidenced CRMs): TMEM50B
- Function elements
- Human SNPs: Eosinophil_counts
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 2
- Related genes and loops