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Basic information

CohesinDB ID: CDBP00417224

Locus: chr21-33171217-33171918

Data sourse: ENCSR000BLD, GSE67783, GSE86191, GSE206145

Cell type: RPE, H1-hESC, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 46%, "13_ReprPC": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOXA1, SUZ12, PBX2, NFIC, PRDM1, ZNF189, TP63, TRIM28, ESR1, TP73, USF2, CTCF, JUN, EP300, MNT, IRF4, KMT2B, PDX1, ZSCAN5D, MYCN, KDM4C, ZBTB48, DUX4, STAT1, ZBTB21, PBX1, ZNF341, MYC, SMARCA4, RFX1, GRHL3, GABPA, XRCC5, IKZF1, RCOR1, NR3C1, SRSF3, EZH2, ZNF436, SPI1, ZNF786, IRF1, INTS13, HCFC1R1, NFYB, ZIM3, SMC1A, NKX2-2, EZH2phosphoT487, ZFX, ZNF534, ZNF770, TET2, CBX8, IRF2, ARNT, ZEB2, PBX3, MAFB, FOS, CDK8, MED1, ZEB1, ZNF250, MYB, L3MBTL2, STAT5A, USF1, SP1, BCL11A, HNF4A, POU2F3, SMC3, STAG1, PAX7, FOXA2, ZSCAN16, GTF2B, WT1, ZBTB33, CDK9, KDM1A, YY1, RELA, NEUROD1, MCM3, SP140, TCF4, HIF1A, ZFP36, ZIC2, BHLHE22, OTX2, TAL1, MAX, SPIB, ZNF143, GATA1, PLAG1, CBX2, NR2F1, PKNOX1, ZBTB6, ZNF334, BRD2, T, AR, RNF2, NOTCH3, BRD4, JUND, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): SYNJ1

Function elements

Human SNPs: Attention_deficit_hyperactivity_disorder

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000159082,

eachgene

Deatailed information for cohesin site CDBP00417224