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Basic information

CohesinDB ID: CDBP00417231

Locus: chr21-33185051-33185236

Data sourse: GSE120943, GSE98367

Cell type: Monocytes, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 56%, "15_Quies": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, FOXO1, POU2F2, CHD8, MYCN, EBF1, RUNX1T1, ZFX, POU4F2, XBP1, ZBTB17, ZBTB48, WT1, ZSCAN5A, STAT1, FOXA1, CDK9, ZNF596, PRDM10, KDM1A, YY1, RELA, ERG, PBX1, LYL1, ETS1, MYC, EZH1, SP140, ZFP36, ZNF48, GATA3, GABPA, TAL1, MAX, ZNF143, MED1, NR3C1, MAF, NR2F2, TRIM28, MYB, STAT5B, ZMYM3, TERF1, EZH2, LMO2, CTCF, TCF12, SP1, SPI1, TBX21, LMO1, PAX8, GATA2, FLI1, ZNF605, BRD4, TCF3, MAZ, SMC3, STAG1

Target gene symbol (double-evidenced CRMs): AP000311.1,IFNAR1,IFNGR2,TMEM50B,CRYZL1,SYNJ1,EVA1C

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000166979, ENSG00000159082, ENSG00000142166, ENSG00000159128, ENSG00000142188, ENSG00000249209, ENSG00000205758,

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Deatailed information for cohesin site CDBP00417231