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Basic information

CohesinDB ID: CDBP00417240

Locus: chr21-33206645-33209519

Data sourse: GSE93080, ENCSR000EAC, ENCSR000DZP, ENCSR230ZWH, GSE104888, GSE86191, GSE138405, GSE98367, GSE76893, GSE62063, GSE120943, ENCSR153HNT, GSE50893, GSE126755, ENCSR917QNE

Cell type: GM2610, Liver, GM2630, GM12890, GM2255, K-562, GM18486, GM18526, SNYDER, Monocytes, GM12878, GM12891, GM2588, GM19239, GM19193, GM19099, Macrophage, Ramos, GM12892, Hela-Kyoto, HCT-116, A-549, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 9% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.722

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 45%, "5_TxWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: CBX5, XBP1, FOXA1, TFAP4, HDGF, THAP1, RUNX3, PAX5, ZNF287, JMJD1C, TRIM28, BCLAF1, ZNF26, ESR1, OCA2, CTCF, TCF12, ZNF695, DPF2, IRF4, TRIM24, SMC1, ZNF280A, EED, POU5F1, RUNX1T1, ZNF317, DUX4, ZSCAN5A, ZBTB48, STAT1, ZNF485, SMARCA4, RAD21, RXRA, STAT3, PRDM14, IKZF1, NFE2, HNRNPH1, VDR, NR3C1, CEBPB, KMT2A, SPI1, ZNF644, GATAD2B, RELB, NFIL3, RUNX1, SMC1A, BCL6, CEBPA, CBX1, ZFX, TRIM22, IRF2, CREBBP, ZNF184, ARNT, ZNF48, CDK8, MED1, TEAD3, TERF1, ZNF680, SETDB1, USF1, SP1, BCL11A, HNF4A, ATF7, TCF3, MLLT1, STAG1, MEF2B, CBX3, EBF1, ZNF662, MEF2C, CDK9, YY1, RELA, ZNF222, MAX, SPIB, ZNF143, KLF4, CEBPG, ZFP69B, NCOA3, NR2F1, ELF3, TBX21, EGR1, ZBTB26, NCOR1, IKZF2, JUND, BRD4, MAZ, ZNF316

Target gene symbol (double-evidenced CRMs): IL10RB,RCAN1,IFNGR2,TMEM50B,SON,AP000311.1,SMIM11A,CRYZL1,ATP5PO,DONSON,ITSN1,IFNAR1,AP000295.1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 8

Related genes and loops

Related gene: ENSG00000249624, ENSG00000243646, ENSG00000142166, ENSG00000159128, ENSG00000142188, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000205670, ENSG00000159200,

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Deatailed information for cohesin site CDBP00417240