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Basic information

CohesinDB ID: CDBP00417243

Locus: chr21-33215011-33217335

Data sourse: ENCSR230ZWH, GSE103477, GSE111537, ENCSR917QNE, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE120943, GSE116344, GSE98367, ENCSR879KXD, GSE206145, GSE62063, ENCSR000BMY, GSE55407, GSE38395, GSE111913, GSE155324, ENCSR153HNT, GSE50893, GSE126755, GSE73207

Cell type: MDM, RH4, GM2610, GM19240, OCI-AML-3, Liver, B-cell, GM2630, GM12890, hLCL, GM2255, K-562, GM18486, GM18526, SNYDER, Monocytes, GM18505, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GM19239, RT-112, GM19193, THP-1, GM19099, Macrophage, Ramos, GM12892, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 15% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.633

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 35%, "15_Quies": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, CBX5, SOX2, FOXA1, ZNF749, SUZ12, RBFOX2, RXRB, TFAP4, HDGF, TSC22D4, LYL1, BMI1, NFIC, ATF3, RUNX3, PRDM1, CHD7, ATF4, CBFB, MECOM, SMARCE1, PAX5, DPF1, TP63, MITF, HDAC3, BACH2, CDX2, JMJD1C, MAF, KLF5, ELF1, TRIM28, BCLAF1, KLF6, SNAI2, LMO2, ESR1, MLL, SMAD5, TP73, HDAC8, OCA2, USF2, CTCF, SND1, TCF12, EP300, JUN, KLF1, MNT, LMO1, E4F1, PYGO2, DPF2, ARID5B, SOX5, E2F6, SIX5, IRF4, TRIM24, CREB3, E2F4, SOX6, RAD51, TEAD4, KMT2B, ZNF175, FOXA3, GTF2F1, EHMT2, RBPJ, EED, GLIS1, POU2F2, NANOG, BRD3, POU5F1, CDK7, ID3, RUNX1T1, CTBP1, MTA2, ZBTB48, STAT1, MLLT3, SRF, DDX5, NBN, SAP130, TBP, HNF4G, ERG, PBX1, ZNF341, NFKB2, MYC, ETS1, SMARCA4, KDM4A, ARID1B, RAD21, FOXP2, GRHL3, RXRA, NKX2-1, FOXK2, BATF3, GABPA, STAT3, ZNF614, XRCC5, IKZF1, LEF1, RCOR1, CD74, NR2F6, VDR, NFE2, NR3C1, ESRRA, CEBPB, ZNF750, STAT5B, ARNTL, KMT2A, CREB1, EZH2, GRHL2, SPI1, HES1, EHF, IRF1, HDAC2, INTS13, GATA2, ZNF644, GATAD2B, FLI1, NR2C2, SMARCA5, RELB, EP400, NFIL3, NFYB, ETV5, RUNX1, SMC1A, BCL6, HDAC1, CEBPA, SIRT6, SOX13, ZFX, SIN3A, SMAD3, TRIM22, MEF2A, IRF2, ZNF384, CREBBP, NOTCH1, ZBTB2, RARA, SMAD2, ARNT, BACH1, PBX4, ZNF48, ATF2, HMBOX1, SMAD4, ZEB2, FOXM1, ETV6, NR2C1, FOS, CDK8, PBX3, MED1, GMEB1, ZEB1, TERF1, PML, MYB, DIDO1, SCRT2, SMAD1, TEAD3, TAF7, L3MBTL2, EVI1, SETDB1, STAT5A, USF1, SP1, NIPBL, BCL11A, HNF4A, NR4A1, MAFK, REST, ZBTB7A, ATF7, ASH2L, AFF1, TCF3, BCOR, FOXP1, STAT2, NCOR2, MLLT1, NFATC3, SKI, CBFA2T2, MEF2B, KLF13, ZNF207, MTA3, EBF1, CREM, PPARG, E2F8, CBX3, FOXA2, GTF2B, ZBED1, NFATC1, RBBP5, FOXF1, MEIS1, MEF2C, ZBTB33, CDK9, BCL3, ZNF318, ZNF589, YY1, RELA, KDM1A, TARDBP, JUNB, NEUROD1, ZNF830, TCF4, SKIL, ZFP36, HIF1A, BHLHE22, GATA3, ZIC2, BATF, MGA, TAL1, MAX, SPIB, GATA1, ZNF143, PLAG1, KLF4, BCL11B, ZNF592, CEBPG, NR2F2, NR2F1, TERF2, NEUROG2, ZNF687, TP53, PKNOX1, MED, ZNF334, NFKB1, MYOD1, ELF3, TBX21, BHLHE40, AR, TAF1, ZBTB16, ZBTB40, RXR, EGLN2, EGR1, RB1, ZBTB26, RNF2, IKZF2, BRD4, ILF3, JUND, NCOR1, SCRT1, MEF2D, AHR

Target gene symbol (double-evidenced CRMs): IFNAR1,RCAN1,AP000295.1,AP000311.1,TMEM50B,SMIM11A,ITSN1,ATP5PO,IL10RB,DONSON,SON,CRYZL1,IFNAR2,IFNGR2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000249624, ENSG00000159110, ENSG00000243646, ENSG00000142166, ENSG00000159128, ENSG00000142188, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000205670, ENSG00000159200,

eachgene

Deatailed information for cohesin site CDBP00417243