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Basic information

CohesinDB ID: CDBP00417247

Locus: chr21-33227306-33234986

Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR917QNE, GSE93080, GSE67783, GSE86191, GSE101921, GSE120943, ENCSR198ZYJ, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR338DUC, ENCSR247LSH, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE131577, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR620NWG, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE111537, GSE25021, ENCSR000EAC, GSE76893, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE73207, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, THP-1, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, TF-1, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, HAP1, Macrophage, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 42% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.367

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 24%, "2_TssAFlnk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, ZNF121, E2F5, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, SOX5, PYGO2, E2F4, ZNF674, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, TOP2A, ZNF263, CTBP1, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, ZNF785, NR2C2, RELB, RUNX1, CEBPA, HDAC1, NKX2-2, ZNF707, REPIN1, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZXDC, ZBTB2, TFDP1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, GMEB1, TERF1, PML, PIAS1, SMAD1, C11orf30, EVI1, STAT5A, GSPT2, IKZF5, ARID2, ZSCAN31, ELL2, HMGB1, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, PAF1, SS18, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, TCF4, ZFP36, BATF, MAF1, PLAG1, ZFP69B, BCL11B, KLF4, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, ILF3, ZNF316, FOSL1, ZNF660, HNF1A, XBP1, KDM4B, PBX2, ZNF596, HNRNPK, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, CDC5L, MAF, INTS11, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, CTCF, TAF3, L3MBTL4, LMO1, ZBTB20, MNT, DPF2, RYBP, IRF4, ZNF423, DDX20, PDX1, RBPJ, MLX, TFAP2C, MTA2, ZNF317, ZBTB48, ZBTB17, ZSCAN21, NONO, SRF, NBN, ONECUT1, KDM4A, HOMEZ, FOXP2, ZNF2, RXRA, MIER3, TERF2, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZSCAN29, SMARCA5, NFIL3, THAP11, EZH2phosphoT487, LDB1, SOX13, AFF4, ZNF770, ZNF513, SP3, ARNT, BACH1, ZNF48, HMBOX1, ZEB2, PBX3, NCAPH2, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, MLLT1, STAG1, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KDM1A, KAT2B, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, TP53, ZNF334, NFKB1, ZSCAN22, PHF5A, BRD2, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, BRD4, CUX1, ZSCAN23, IRF9, PGR, SOX2, PATZ1, RING1B, UBTF, LEO1, TFAP4, SIN3B, CHD7, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, ZNF217, ESR1, SAP30, ZNF524, SND1, KLF1, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, NCOA2, ZNF76, ZNF554, ETV5, GTF2A2, BCL6, SIN3A, ERG3, RARA, NFYC, ZNF384, CREBBP, TAF15, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, NCOA1, RBM22, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PTTG1, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF574, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, ZNF791, PKNOX1, MYOD1, T, AR, ZNF324, HEXIM1, DMAP1, AHR, ZNF391, HMG20A, LCORL, ZSCAN5C, HMGN3, MEIS2, RBFOX2, ZFHX2, SFMBT1, ZNF90, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, ZNF506, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, SOX6, CREB3, E2F1, SMC1, TEAD4, FOXA3, ZNF175, ATRX, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, ZNF205, GATAD1, ARID3A, ZNF300, ZNF341, EOMES, RAD21, GRHL3, ZNF614, XRCC5, NFE2, ZNF639, ZNF750, JMJD6, TFE3, HBP1, IRF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, PRPF4, NOTCH1, RUNX2, SMAD2, GATA4, CDK6, ZNF184, ZSCAN30, OSR2, PBX4, NRF1, NR2C1, SUPT5H, CHD1, FOS, MED1, CEBPD, MYB, SCRT2, KDM6B, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, ZNF283, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF610, BRCA1, SP140, HIF1A, BHLHE22, OTX2, GATA1, CEBPG, SP7, NR2F2, ZNF512, ZNF687, NFKBIZ, BHLHE40, PTRF, TAF1, ZBTB40, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): ATP5PO,ITSN1,AP000311.1,AP000295.1,IFNGR2,IFNAR2,TMEM50B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 231

Number of somatic mutations (non-coding): 17

Related genes and loops

Related gene: ENSG00000249624, ENSG00000159110, ENSG00000159128, ENSG00000142188, ENSG00000249209, ENSG00000205726, ENSG00000241837,

eachgene

Deatailed information for cohesin site CDBP00417247