Deatailed information for cohesin site CDBP00417248

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  • Basic information
  • CohesinDB ID: CDBP00417248
  • Locus: chr21-33235935-33240451
  • Data sourse: GSE93080, ENCSR000EAC, ENCSR000DZP, GSE67783, GSE86191, GSE98367, GSE155324, GSE206145, GSE62063, ENCSR000BMY, ENCSR153HNT, GSE120943, GSE83726, GSE116344, GSE50893, GSE73207
  • Cell type: RH4, GM2610, B-cell, RPE, GM2630, GM12890, K-562, GM18486, GM18526, SNYDER, Monocytes, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GM19239, Macrophage, Ramos, GM12892, HCT-116, GM19238, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 8% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.744
  • Subunit: NIPBL,SA1,Rad21,SMC1,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 93% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 41%, "7_Enh": 26%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: NFIA, SOX2, XBP1, FOXA1, LEO1, HDGF, TSC22D4, ATF3, NFIC, ZFP64, RUNX3, MORC2, CBFB, MECOM, PAX5, ZSCAN4, MAF, JMJD1C, BCLAF1, TRIM28, ZNF121, SMAD5, ESR1, OCA2, TP73, LMO2, USF2, CTCF, TCF12, JUN, EP300, SND1, ZBTB20, DPF2, PRDM4, TRIM24, IRF4, E2F4, RAD51, E2F1, ZNF528, TEAD4, RBPJ, EED, POU2F2, CHD8, MYCN, ZNF263, MTA2, ZBTB48, STAT1, NBN, ARID3A, ERG, NFKB2, ZNF341, EZH1, MYC, SMARCA4, ONECUT1, RAD21, GRHL3, RXRA, BATF3, GABPA, STAT3, XRCC5, IKZF1, TERF2, NR3C1, CEBPB, SRSF3, STAT5B, KMT2A, CREB1, EZH2, BMPR1A, SPI1, GATA2, MXD3, FLI1, SMARCA5, RELB, HCFC1R1, ATF1, RUNX1, BCL6, SMC1A, LDB1, SIN3A, ZFX, ZNF534, TRIM22, MEF2A, ZBTB2, ZNF384, NOTCH1, RUNX2, GATA4, ZNF184, NFIB, ARNT, BACH1, ZNF48, ATF2, CBFA2T3, FOXM1, ETV6, SUPT5H, CDK8, FOS, PBX3, MED1, TEAD3, PML, CEBPD, MYB, TERF1, ZMYM3, SMAD1, SETDB1, STAT5A, RBM22, USF1, BCL11A, NIPBL, GSPT2, HNF4A, NR4A1, SP1, REST, ATF7, POU2F3, ASH2L, TCF3, FOXP1, BCOR, SMC3, STAT2, MLLT1, STAG1, NFATC3, MEF2B, PPARG, MTA3, CREM, EBF1, PAF1, E2F8, NFATC1, ZBED1, WT1, GTF2B, MEF2C, ZBTB33, CDK9, BCL3, MPHOSPH8, YY1, RELA, TARDBP, JUNB, SP140, ZIC2, HIF1A, SKIL, TCF4, OTX2, BATF, TAL1, MAX, ZNF143, AGO2, MTA1, GATA1, NCOA3, TP53, PKNOX1, ZNF334, NFKB1, TBX21, BHLHE40, AR, TAF1, EGLN2, HSF1, NOTCH3, BRD4, JUND, IKZF2, MAZ, AHR
  • Target gene symbol (double-evidenced CRMs): AP000311.1,AP000295.1,ATP5PO,ITSN1,IFNAR2,IFNGR2,TMEM50B
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 115
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000249624, ENSG00000159110, ENSG00000159128, ENSG00000142188, ENSG00000249209, ENSG00000205726, ENSG00000241837,
  • Related loop: chr21:33203382-33204703~~chr21:33228821-33231810, chr21:33214816-33217343~~chr21:33229592-33232534, chr21:33215057-33217255~~chr21:33229646-33232564, chr21:33215072-33217019~~chr21:33229162-33232141, chr21:33225000-33250000~~chr21:33425000-33450000, chr21:33225000-33250000~~chr21:33875000-33900000,
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