- Basic information
- CohesinDB ID: CDBP00417250
- Locus: chr21-33242428-33243401
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Data sourse: GSE67783, GSE86191, GSE98367, GSE206145-NatGen2015, GSE120943, ENCSR153HNT
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Cell type: Fibroblast, HCT-116, Monocytes, K-562, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
93% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 60%,
"4_Tx": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, HMG20A, LCORL, ZNF496, SOX2, NME2, XBP1, FOXA1, HLF, PBX2, RXRB, KDM3A, TFAP4, HNRNPK, HDGF, LYL1, ATF3, NFIC, THRB, RUNX3, PRDM1, CHD7, MXD4, MECOM, ZSCAN4, JMJD1C, MAF, TEAD1, TRIM28, BCLAF1, RCOR2, ESR1, MLL, LMO2, CTCF, JUN, TCF12, EP300, ARID5B, LMO1, MNT, GATA6, SOX5, TRIM24, FOXA3, GATAD2A, MLX, EED, RBPJ, POU2F2, CHD8, NANOG, POU5F1, CDK7, RUNX1T1, ZBTB48, STAT1, SRF, SAP130, ARID3A, HNF4G, ERG, PBX1, SMARCC2, ETS1, MYC, ONECUT1, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, GABPA, ZNF614, XRCC5, IKZF1, MIER3, NR2F6, ARNTL, NR3C1, CEBPB, STAT5B, KMT2A, CREB1, EZH2, TBL1XR1, ZNF652, SPI1, MIXL1, ZNF664, HDAC2, GATA2, ZNF644, FLI1, DRAP1, ZGPAT, NFIL3, NCOA2, ETV5, RUNX1, THAP11, SMC1A, BCL6, CEBPA, SOX13, ZFX, POU4F2, MYBL2, RARA, NOTCH1, RUNX2, CDK6, GATA4, ARNT, ZNF48, PRDM9, SMAD4, PBX3, SUPT5H, CDK8, MED1, TEAD3, CEBPD, MYB, SMAD1, EVI1, RBM22, USF1, BCL11A, SP1, NR4A1, HNF4A, IKZF5, REST, RBM25, ASH2L, TCF3, FOXP1, SMC3, MLLT1, STAG1, SKI, MEF2B, PPARG, FOXA2, CBX3, CREM, MEIS1, MIER2, GTF2B, WT1, ZBTB33, MEF2C, CDK9, HOXB13, ZKSCAN1, ZNF580, KDM1A, YY1, RELA, NEUROD1, KAT2B, TCF4, OTX2, GATA3, TAL1, MAX, GATA1, ZNF143, CEBPG, NR2F2, TCF7L2, NEUROG2, PKNOX1, MED, ZNF334, PHF5A, ELF3, KAT8, T, TBX21, ARID4B, AR, NFKBIZ, ZBTB26, NOTCH3, BRD4, JUND, CLOCK, CUX1
- Target gene symbol (double-evidenced CRMs): IFNGR2,AP000295.1,AP000311.1,TMEM50B,IFNAR2,ATP5PO,ITSN1
- Function elements
- Human SNPs: COVID-19_(critical_illness_vs_population)
- Number of somatic mutations (coding): 30
- Number of somatic mutations (non-coding): 6
- Related genes and loops