- Basic information
- CohesinDB ID: CDBP00417260
- Locus: chr21-33263925-33265036
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Data sourse: GSE118494, GSE67783, GSE86191, GSE98367, ENCSR153HNT, GSE83726, GSE116344
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Cell type: HCT-116, RH4, IMR-90, K-562, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 60%,
"4_Tx": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, PAX5, SFPQ, TEAD1, OCA2, MED26, HDAC8, ZNF561, E4F1, ARID5B, SOX5, E2F4, DEK, ZNF528, NR5A2, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, TOP2A, ZNF263, CTBP1, STAT1, ZNF134, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, KLF17, GATA2, MXD3, FLI1, DRAP1, MXI1, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, CRY1, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, PML, TERF1, PIAS1, SMAD1, NR1H2, EVI1, MBD1, STAT5A, IKZF5, ARID2, AFF1, MBD2, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, PAF1, WT1, MEF2C, NEUROD1, JUNB, TCF4, ZFP36, BATF, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZBTB26, NCOR1, HSF1, ILF3, ZNF316, ZNF660, XBP1, KDM4B, ZNF101, PBX2, SRSF4, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, ZNF273, TP63, MITF, BACH2, ZNF467, JMJD1C, INTS11, MAF, ELF1, ZNF573, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, RYBP, DPF2, IRF4, PDX1, TFAP2C, MLX, RBPJ, MTA2, ZBTB17, ZBTB48, NONO, DDX5, NBN, KDM4A, HOMEZ, FOXP2, RXRA, BATF3, NKX3-1, PRDM14, MIER3, HNRNPH1, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SMARCA5, NFIL3, THAP11, CTNNB1, SOX13, AFF4, ZNF770, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, BACH1, NFIB, ZNF48, PRDM9, HMBOX1, ZEB2, ETV6, NCAPH2, ZNF10, PBX3, HMGXB4, MAFB, TEAD3, ZXDB, U2AF1, KLF9, USF1, SP1, BCL11A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, SMC3, MLLT1, STAG1, STAG2, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, IKZF2, BRD4, JUND, ZNF468, PGR, PATZ1, LEO1, UBTF, TFAP4, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, SND1, KLF1, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZSCAN5A, ELK4, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, NCOA2, ETV5, BCL6, SIN3A, ERG3, MEF2A, CREBBP, RARA, ZNF35, ZNF384, TAF15, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, SUPT16H, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, FOXO3, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, PKNOX1, MYOD1, AR, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, HMGN3, SUZ12, RBFOX2, ZNF28, ZFHX2, SFMBT1, LYL1, NFIC, ZNF362, CTCFL, MECOM, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, ZNF26, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, MLLT3, GATAD1, ARID3A, USP7, MIER1, ZNF341, ASCL1, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, ZNF93, TFE3, HBP1, EHF, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, PBX4, SUPT5H, CHD1, FOS, MED1, KDM6B, MYB, CEBPD, SCRT2, VEZF1, ZNF3, L3MBTL2, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, ZNF519, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ
- Target gene symbol (double-evidenced CRMs): AP000295.1,IL10RB,IFNAR2,IFNAR1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 13
- Number of somatic mutations (non-coding): 9
- Related genes and loops