- Basic information
- CohesinDB ID: CDBP00417270
- Locus: chr21-33285676-33297310
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Data sourse: ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE116868, ENCSR150EFU, GSE25021, ENCSR330ELC, GSE108869, ENCSR917QNE, GSE165895, ENCSR000BTU, GSE93080, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, GSE116344, GSE98367, ENCSR193NSH, ENCSR000BLS, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR000BMY, ENCSR620NWG, GSE62063, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR167MTG, ENCSR853VWZ, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE38411
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Cell type: RH4, Liver, HuCC-T1, RPE, Fibroblast, Ishikawa, HeLa-S3, K-562, BCBL-1, HFFc6, SNYDER, Monocytes, MB157, GM12878, GM12891, RT-112, Macrophage, Ramos, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HCAEC, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 16% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.722
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TES,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 39%,
"4_Tx": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, PGR, HMG20A, XBP1, FOXA1, LEO1, RXRB, MLL4, ZFHX2, TFAP4, ATF3, ZC3H8, NFIC, CHD7, MORC2, CBFB, MXD4, SMARCE1, TP63, CDX2, KLF5, ELF1, TEAD1, ZNF121, ETV1, KLF6, SNAI2, RCOR2, ESR1, OCA2, TP73, MED26, USF2, CTCF, TCF12, JUN, EP300, KLF1, BAF155, SOX5, PAX8, DMAP1, RFX5, DEK, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, RBPJ, TFAP2C, GLIS1, POU2F2, CHD8, ZSCAN5D, MYCN, POU5F1, ZNF263, KDM4C, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, TBP, HNF4G, ERG, ASCL1, MYC, ONECUT1, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, PROX1, NKX2-1, GABPA, STAT3, XRCC5, UBN1, ZNF614, IKZF1, MIER3, HNRNPH1, NR2F6, RCOR1, ARNTL, VDR, NR3C1, CEBPB, HNRNPL, CREB1, TBL1XR1, EZH2, GABPB1, SPI1, TFE3, EHF, MIXL1, KLF17, HDAC2, GATA2, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, HCFC1R1, NFIL3, MRTFB, ETV5, RUNX1, THAP11, CTNNB1, BCL6, SMC1A, CEBPA, ZBTB24, CRY1, SOX13, ZFX, AFF4, SIN3A, SMAD3, TET2, ERG3, ZNF770, SP5, SMARCC1, PRDM10, RARA, PRPF4, CREBBP, RUNX2, CDK6, PBX4, DAXX, NFIB, NRF1, ZNF48, PRDM9, SMAD4, FOXM1, SUPT5H, SMARCB1, FOS, MED1, TEAD3, ZXDB, KDM6B, SCRT2, PIAS1, ZNF3, KLF9, C11orf30, RBM22, USF1, SP1, MAFK, GSPT2, HNF4A, BCL11A, IKZF5, REST, ZBTB7A, ZHX1, ASH2L, HNRNPLL, PHIP, TCF3, FOXP1, GLIS2, AATF, SMC3, ELL2, STAG1, STAG2, ZNF394, SKI, NELFA, TRP47, CBFA2T2, PPARG, AGO1, FOXA2, ZNF316, MEIS1, CHD2, ZNF600, ZNF692, GTF2B, WT1, MAFF, ESR2, ZBTB33, TCF7, ZNF580, KLF7, KDM1A, YY1, RELA, JUNB, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, AGO2, GATA1, HAND2, PLAG1, CBX2, CEBPG, KLF4, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, ZNF334, NFKB1, ELF3, BRD2, KAT8, ARID4B, AR, BHLHE40, NFKBIZ, TAF1, RXR, EGR1, HSF1, ZBTB26, NCOR1, BRD4, JUND, SCRT1, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): SMIM11A,IL10RB,AP000295.1,EVA1C,URB1
- Function elements
- Human SNPs: Interleukin-10_receptor_B_levels
- Number of somatic mutations (coding): 162
- Number of somatic mutations (non-coding): 125
- Related genes and loops
- Related gene:
ENSG00000142207,
ENSG00000166979,
ENSG00000249624,
ENSG00000243646,
ENSG00000205670,
- Related loop:
chr21:32375000-32400000~~chr21:33275000-33300000,
chr21:32450000-32475000~~chr21:33275000-33300000,
chr21:32825000-32850000~~chr21:33300000-33325000,
chr21:32950000-32975000~~chr21:33300000-33325000,
chr21:33200000-33225000~~chr21:33300000-33325000,
chr21:33275000-33300000~~chr21:34350000-34375000,