- Basic information
- CohesinDB ID: CDBP00417272
- Locus: chr21-33303454-33305756
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Data sourse: ENCSR167MTG, ENCSR230ZWH, ENCSR000BKV, GSE67783, GSE72082, GSE86191, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145-NatGen2015, ENCSR054FKH, GSE120943, ENCSR153HNT, GSE73207, GSE126755, ENCSR917QNE
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Cell type: Fibroblast, HCT-116, Monocytes, Hep-G2, TF-1, K-562, Liver, Neutrophil, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 51%,
"5_TxWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, ZBTB44, ZNF322, PAX5, TEAD1, E2F5, LMO2, OCA2, PITX3, HDAC8, ZNF507, E4F1, SOX5, PYGO2, ZNF410, KMT2B, GATAD2A, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, SMARCA4, FOXK2, RCOR1, CD74, NR2F6, CEBPB, CREB1, GABPB1, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, NR2C2, RELB, RUNX1, HDAC1, CEBPA, SMARCC1, PRDM10, ZBTB2, ATF2, FOXM1, SMARCB1, ZNF584, GMEB1, TERF1, PML, PIAS1, SMAD1, C11orf30, EVI1, IKZF5, RBM25, ZSCAN31, AFF1, MBD2, ETV4, CBFA2T2, MEF2B, CBX3, CREM, CHD2, PAF1, WT1, MEF2C, JUNB, ZFP36, TCF4, SPIB, KLF4, BCL11B, ZKSCAN8, ZBTB6, ELF3, ARID4B, RXR, MAML3, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, XBP1, PBX2, THRB, ATF3, RUNX3, MITF, BACH2, MAF, INTS11, JMJD1C, ELF1, SNAI2, JUN, CTCF, LMO1, DPF2, IRF4, DDX20, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, NONO, DDX5, NBN, PBX1, ONECUT1, HOMEZ, FOXP2, RXRA, NKX3-1, LEF1, TERF2, HNRNPH1, MIER3, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, TBL1XR1, GRHL2, EBF3, SMARCA5, NFIL3, THAP11, LDB1, SOX13, ZMIZ1, ARNT, BACH1, ZNF48, ZEB2, HMBOX1, ETV6, MAFB, HMGXB4, TEAD3, DIDO1, TAF7, USF1, BCL11A, SP1, ATF7, ASH2L, SMC3, STAG2, STAG1, MTA3, EBF1, MEIS1, MAFF, ZNF580, BCL3, KDM1A, ISL1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, TP53, ZNF334, NFKB1, PHOX2B, BRD2, KAT8, TBX21, EGR1, RB1, RNF2, IKZF2, BRD4, JUND, CUX1, IRF9, TBX2, ZNF496, SOX2, LEO1, TFAP4, CHD7, MXD4, SMARCE1, KLF6, NFE2L2, ESR1, KLF1, SOX4, E2F6, TRIM24, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZSCAN5A, HNF4G, SMARCC2, ETS1, MYC, ARID1B, GABPA, STAT3, IKZF1, GFI1, SRSF3, EZH2, ZNF652, SPI1, HDAC2, INTS13, ETV5, GTF2A2, BCL6, ERG3, MYBL2, CREBBP, ZNF35, RARA, ZNF384, ZNF354B, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, GTF3C2, MAFK, NR4A1, HNF4A, REST, ARID1A, BCOR, FOXP1, NCOR2, ILK, PTTG1, PPARG, GTF2B, ZNF30, RELA, TARDBP, CHAMP1, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, PKNOX1, MYOD1, AR, PAX3-FOXO1, ZBTB16, ZNF324, ZNF395, DMAP1, AHR, HMG20A, MEIS2, SUZ12, ZFHX2, LYL1, MECOM, CDX2, KLF5, TRIM28, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, CREB3, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, RUNX1T1, ID3, HINFP, MLLT3, GATAD1, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, ZNF750, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, SMC1A, MAFG, CBX1, ZFX, ZNF534, SMAD3, TWIST1, NSD2, NOTCH1, RUNX2, GATA4, OSR2, PBX4, NRF1, NR2C1, FOS, MED1, CEBPD, MYB, SCRT2, L3MBTL2, KLF16, ZBTB7A, CCNT2, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, SP140, HIF1A, ZNF740, GATA1, HAND2, TLE3, CEBPG, NCOA3, NR2F2, ZNF83, BHLHE40, PTRF, TAF1, ZBTB40, ZBTB42, NOTCH3, MAZ, MEF2D, ZNF24
- Target gene symbol (double-evidenced CRMs): IFNAR2,AP000295.1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops