- Basic information
- CohesinDB ID: CDBP00417293
- Locus: chr21-33346315-33351403
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Data sourse: ENCSR000BLD, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, GSE126634, GSE116868, ENCSR000EGW, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, GSE25021, ENCSR000EFJ, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, GSE138105, ENCSR703TNG, GSE116344, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, ENCSR620NWG, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR000ECS
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Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, OCI-AML-3, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, GM12878, GM12891, GM2588, SK-N-SH, GM19239, GM19193, HAP1, GM19099, Macrophage, MCF-7, GM12892, THP-1, Hela-Kyoto, HCT-116, Hep-G2, A-549, HCAEC, GM19238, HeLa, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 27% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.489
- Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 45%,
"5_TxWk": 42%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: CHD8, FOXA2, ZFX, XBP1, DUX4, FOXA1, ZNF205, ZBTB33, ERG, HDGF, AHR, PRDM1, SUPT5H, MITF, DACH1, ZNF736, ZNF141, ZNF121, TRIM28, EZH2, CTCF, SPI1, SRSF9, ZNF316
- Target gene symbol (double-evidenced CRMs): IFNAR2,AP000311.1,TMEM50B,IFNGR2,PAXBP1,AP000295.1,IFNAR1,IL10RB,SYNJ1,CRYZL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 63
- Number of somatic mutations (non-coding): 62
- Related genes and loops
- Related gene:
ENSG00000159082,
ENSG00000159086,
ENSG00000249624,
ENSG00000159110,
ENSG00000243646,
ENSG00000142166,
ENSG00000159128,
ENSG00000142188,
ENSG00000249209,
ENSG00000205758,
- Related loop:
chr21:32725000-32750000~~chr21:33350000-33375000,
chr21:32825000-32850000~~chr21:33350000-33375000,
chr21:32925000-32950000~~chr21:33325000-33350000,
chr21:33025000-33050000~~chr21:33325000-33350000,
chr21:33175000-33200000~~chr21:33350000-33375000,
chr21:33200000-33225000~~chr21:33325000-33350000,
chr21:33200000-33225000~~chr21:33350000-33375000,
chr21:33250000-33275000~~chr21:33350000-33375000,
chr21:33325000-33350000~~chr21:33425000-33450000,
chr21:33325000-33350000~~chr21:33450000-33475000,
chr21:33350000-33375000~~chr21:33450000-33475000,
chr21:33350000-33375000~~chr21:33600000-33625000,