- Basic information
- CohesinDB ID: CDBP00417297
- Locus: chr21-33359012-33364862
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE64758, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, CNCC-WT33iPSC, TC-71, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 78% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.167
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 31%,
"5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: SKI, BCL6, CEBPA, CREM, ZFX, ZBTB48, SMAD3, STAT1, MEF2C, RELA, ZNF384, EHMT2, ARNT, HIF1A, STAT3, MAX, FOS, CDK8, MED1, CDX2, CEBPB, JMJD1C, ELF1, TRIM28, KMT2A, CREB1, EPAS1, ZNF121, RCOR2, L3MBTL2, ELF3, CTCF, JUN, SPI1, BCL11A, EGLN2, RBM25, FLI1, BRD4, JUND, BCOR, E2F1, MLLT1
- Target gene symbol (double-evidenced CRMs): CRYZL1,IFNAR2,IL10RB,SYNJ1,AP000311.1,TMEM50B,AP000295.1,IFNAR1,PAXBP1
- Function elements
- Human SNPs: Cognitive_decline_(age-related)
- Number of somatic mutations (coding): 1
- Number of somatic mutations (non-coding): 22
- Related genes and loops
- Related gene:
ENSG00000159082,
ENSG00000159086,
ENSG00000249624,
ENSG00000159110,
ENSG00000243646,
ENSG00000142166,
ENSG00000142188,
ENSG00000249209,
ENSG00000205758,
- Related loop:
chr21:32652779-32654447~~chr21:33360228-33362109,
chr21:32725000-32750000~~chr21:33350000-33375000,
chr21:32825000-32850000~~chr21:33350000-33375000,
chr21:33175000-33200000~~chr21:33350000-33375000,
chr21:33199037-33200983~~chr21:33360047-33362483,
chr21:33199045-33200951~~chr21:33360197-33362875,
chr21:33199050-33200800~~chr21:33360051-33362614,
chr21:33199054-33200784~~chr21:33360453-33362457,
chr21:33199055-33201024~~chr21:33360153-33362582,
chr21:33199061-33200994~~chr21:33360009-33362674,
chr21:33199063-33200997~~chr21:33360045-33362734,
chr21:33199071-33200963~~chr21:33360153-33362100,
chr21:33199075-33200850~~chr21:33360213-33362978,
chr21:33199075-33200916~~chr21:33360017-33362749,
chr21:33199076-33200916~~chr21:33360130-33362524,
chr21:33199079-33200988~~chr21:33360176-33362505,
chr21:33199086-33200764~~chr21:33360477-33362524,
chr21:33199100-33200791~~chr21:33360203-33362100,
chr21:33199124-33200675~~chr21:33360104-33362934,
chr21:33199158-33200742~~chr21:33360558-33362130,
chr21:33200000-33225000~~chr21:33350000-33375000,
chr21:33250000-33275000~~chr21:33350000-33375000,
chr21:33350000-33375000~~chr21:33450000-33475000,
chr21:33350000-33375000~~chr21:33600000-33625000,
chr21:33360009-33362674~~chr21:33444395-33446546,
chr21:33360017-33362749~~chr21:33373161-33376136,
chr21:33360017-33362749~~chr21:33444399-33446509,
chr21:33360045-33362734~~chr21:33444390-33446463,
chr21:33360121-33362991~~chr21:33373327-33376082,
chr21:33360121-33362991~~chr21:33444374-33446510,
chr21:33360130-33362524~~chr21:33444431-33446547,
chr21:33360132-33362704~~chr21:33444396-33446544,
chr21:33360151-33362730~~chr21:33373805-33376073,
chr21:33360151-33362730~~chr21:33443867-33446335,
chr21:33360153-33362582~~chr21:33444393-33446535,
chr21:33360157-33362875~~chr21:33444546-33446097,
chr21:33360173-33362129~~chr21:33444604-33446075,
chr21:33360203-33362100~~chr21:33444407-33446481,
chr21:33360213-33362978~~chr21:33444400-33446333,
chr21:33360224-33362415~~chr21:33444418-33446468,
chr21:33360228-33362109~~chr21:33444451-33446541,
chr21:33360313-33362104~~chr21:33444549-33446058,