- Basic information
- CohesinDB ID: CDBP00417299
- Locus: chr21-33367651-33369218
-
Data sourse: ENCSR000BLD, GSE98367, ENCSR879KXD, GSE105028, GSE120943, ENCSR153HNT, GSE126755, GSE73207
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Cell type: H1-hESC, Monocytes, TF-1, K-562, Neutrophil, Macrophage, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SMC3,SA1,Rad21,SMC1
-
CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"9_Het": 57%,
"15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: CBX5, SOX2, NME2, PBX2, LYL1, NFIC, ZBTB5, PRDM1, ZNF189, SMARCE1, MECOM, TP63, JMJD1C, KLF5, ELF1, TRIM28, SNAI2, ZNF217, TP73, ZNF561, JUN, CTCF, TCF12, EP300, KLF1, BAF155, DPF2, TRIM24, SOX6, ZNF410, ZNF280A, TEAD4, EHMT2, EED, NANOG, CHD8, XRCC3, POU2F2, POU5F1, MYCN, ID3, CTBP1, ZNF317, ZSCAN21, MTA2, STAT1, HINFP, SP4, TBP, ERG, ZBTB21, SMARCC2, MYC, SMARCA4, ARID1B, GRHL3, GABPA, STAT3, IKZF1, RCOR1, NFE2, NR2F6, ARNTL, NR3C1, CEBPB, HNRNPL, KMT2A, TBL1XR1, KLF8, SPI1, HDAC2, GATA2, ZNF644, HCFC1, RELB, CC2D1A, RUNX1, CBX1, HDAC1, SIRT6, LDB1, SOX13, ZFX, PALB2, ZMIZ1, ZNF18, ZBTB2, NOTCH1, ZNF184, ARNT, ATF2, ZNF518A, ZEB2, HMBOX1, CBFA2T3, FOXM1, NR2C1, CDK8, MED1, PML, CEBPD, MYB, ZNF680, PIAS1, ZMYM3, SMAD1, ZNF3, NCOA1, GTF3C2, L3MBTL2, SETDB1, EVI1, KLF16, MAFK, SP1, USF1, BCL11A, HNF4A, REST, ZBTB7A, HNRNPLL, PHIP, BCOR, AFF1, TCF3, MLLT1, ZNF394, SKI, CBFA2T2, ZNF316, CBX3, MTA3, CREM, EBF1, PPARG, ZBED1, WT1, MEF2C, TCF7, ZKSCAN1, MPHOSPH8, KDM1A, RELA, TARDBP, JUNB, NEUROD1, CHAMP1, ZFP36, SKIL, HIF1A, TAL1, MAX, ZNF449, ZNF143, MTA1, GATA1, SP7, GFI1B, NR2F2, ZNF512, NR2F1, TP53, PKNOX1, NFKB1, ZNF140, BHLHE40, TAF1, ZBTB40, ZNF366, ZNF280D, MYNN, RNF2, NCOR1, BRD4, ILF3, JUND, MAZ, ZNF24, ADNP, AHR
- Target gene symbol (double-evidenced CRMs): PAXBP1,SYNJ1,IFNAR2,AP000311.1,AP000295.1,TMEM50B,IL10RB,CRYZL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 15
- Related genes and loops
- Related gene:
ENSG00000159082,
ENSG00000159086,
ENSG00000249624,
ENSG00000159110,
ENSG00000243646,
ENSG00000142188,
ENSG00000249209,
ENSG00000205758,
- Related loop:
chr21:32725000-32750000~~chr21:33350000-33375000,
chr21:32825000-32850000~~chr21:33350000-33375000,
chr21:33175000-33200000~~chr21:33350000-33375000,
chr21:33198398-33200659~~chr21:33373911-33375521,
chr21:33199025-33201086~~chr21:33373747-33375905,
chr21:33199037-33200983~~chr21:33373772-33376036,
chr21:33199045-33200951~~chr21:33360197-33362875,
chr21:33199045-33200951~~chr21:33373804-33376065,
chr21:33199050-33200800~~chr21:33373781-33376153,
chr21:33199050-33200857~~chr21:33373787-33375924,
chr21:33199055-33201024~~chr21:33373597-33375828,
chr21:33199058-33200673~~chr21:33373965-33375569,
chr21:33199058-33200767~~chr21:33373905-33375710,
chr21:33199059-33200758~~chr21:33373019-33376113,
chr21:33199061-33200994~~chr21:33360009-33362674,
chr21:33199061-33200994~~chr21:33373693-33376103,
chr21:33199063-33200997~~chr21:33360045-33362734,
chr21:33199063-33200997~~chr21:33373686-33376129,
chr21:33199063-33201023~~chr21:33373680-33375788,
chr21:33199064-33200992~~chr21:33373698-33376058,
chr21:33199071-33200963~~chr21:33373671-33376017,
chr21:33199075-33200850~~chr21:33360213-33362978,
chr21:33199075-33200850~~chr21:33373649-33376041,
chr21:33199075-33200916~~chr21:33360017-33362749,
chr21:33199079-33200988~~chr21:33373770-33375893,
chr21:33199087-33200894~~chr21:33373730-33375882,
chr21:33199094-33200842~~chr21:33373665-33375712,
chr21:33199095-33200896~~chr21:33374154-33375564,
chr21:33199100-33200791~~chr21:33373764-33375895,
chr21:33199124-33200675~~chr21:33360104-33362934,
chr21:33199124-33200675~~chr21:33373671-33376085,
chr21:33199168-33200811~~chr21:33373895-33375674,
chr21:33199174-33200665~~chr21:33373871-33376085,
chr21:33200000-33225000~~chr21:33350000-33375000,
chr21:33250000-33275000~~chr21:33350000-33375000,
chr21:33350000-33375000~~chr21:33450000-33475000,
chr21:33350000-33375000~~chr21:33600000-33625000,
chr21:33360009-33362674~~chr21:33444395-33446546,
chr21:33360017-33362749~~chr21:33373161-33376136,
chr21:33360017-33362749~~chr21:33444399-33446509,
chr21:33360045-33362734~~chr21:33444390-33446463,
chr21:33360121-33362991~~chr21:33373327-33376082,
chr21:33360121-33362991~~chr21:33444374-33446510,
chr21:33360132-33362704~~chr21:33444396-33446544,
chr21:33360151-33362730~~chr21:33373805-33376073,
chr21:33360151-33362730~~chr21:33443867-33446335,
chr21:33360157-33362875~~chr21:33444546-33446097,
chr21:33360213-33362978~~chr21:33444400-33446333,