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Basic information

CohesinDB ID: CDBP00417304

Locus: chr21-33385830-33386823

Data sourse: ENCSR000BLD, GSE72082, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE103477, GSE25021, GSE108869, ENCSR000EDW, ENCSR000EFJ, ENCSR000DZP, GSE143937, ENCSR000BKV, GSE86191, GSE120943, ENCSR000EEG, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE97394, GSE55407, GSE110061, GSE129526, ENCSR000HPG, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE50893, GSE126755, GSE73207

Cell type: MDM, HuCC-T1, H9-hESC, RPE, HeLa-S3, IMR-90, K-562, GM18526, H1-hESC, Monocytes, TF-1, GM12878, SK-N-SH, THP-1, Macrophage, HUES64, MCF-7, HCT-116, Hep-G2, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 10% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.767

Subunit: SMC3,Rad21,SA1,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 57%, "7_Enh": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, MLL4, KDM3A, HDGF, PAX5, SNAPC1, TEAD1, E2F5, ZNF121, OCA2, MED26, HDAC8, E4F1, ARID5B, SOX5, E2F4, DEK, KMT2B, GATAD2A, BRD3, ZNF263, POU5F1, TOP2A, CTBP1, DUX4, STAT1, SAP130, ERG, ZNF597, NFKB2, EZH1, SMARCA4, FOXK2, ZNF398, RCOR1, NR2F6, CD74, NFRKB, DACH1, CEBPB, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, NR2C2, HCFC1, RELB, EP400, RUNX1, HDAC1, CEBPA, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, SOX11, ELK1, ATF2, FOXM1, SP2, SMARCB1, ZNF584, GMEB1, TERF1, PML, SMAD1, C11orf30, EVI1, MBD1, STAT5A, IKZF5, ARID2, RBM25, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, ZFP36, TCF4, BATF, SPIB, PLAG1, KLF4, BCL11B, IRF5, MED, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, ILF3, ADNP, ZNF316, FOSL1, XBP1, PBX2, TSC22D4, THRB, ZC3H8, ATF3, ZFP64, RUNX3, CBFB, DPF1, TP63, MITF, BACH2, MAF, JMJD1C, INTS11, ELF1, ZNF573, RBM39, SNAI2, SMAD5, CTCF, JUN, TAF3, MNT, LMO1, DPF2, IRF4, DDX20, MLX, TFAP2C, RBPJ, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, DDX5, NBN, PHB2, CHD4, HOMEZ, FOXP2, RXRA, MIER3, TERF2, LEF1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, GRHL2, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, ARNT, DAXX, BACH1, ZNF48, PRDM9, ZEB2, HMBOX1, NFYA, ETV6, PBX3, HMGXB4, TEAD3, DIDO1, U2AF1, TAF7, KLF9, USF1, SP1, BCL11A, NKX2-5, ATF7, ASH2L, SMC3, MLLT1, STAG1, STAG2, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, KDM1A, GATA3, TAL1, NRIP1, ZNF143, MTA1, TP53, ZNF334, NFKB1, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, RNF2, IKZF2, BRD4, JUND, SMAD4.1D12, PGR, CBX5, SOX2, PATZ1, UBTF, TFAP4, SIN3B, BMI1, SETX, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, SND1, KLF1, SOX4, E2F6, TRIM24, U2AF2, GTF2F1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, TBP, HNF4G, HOXC5, SMARCC2, ETS1, MYC, ARID1B, ZNF24, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, DNMT3B, EZH2, ZNF652, PHF8, SPI1, HDAC2, INTS13, GATAD2B, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, CREBBP, NFYC, ZNF384, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, GTF3C2, ZNF22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, BCOR, FOXP1, NCOR2, PPARG, TBL1X, GTF2B, TCF7, FOXO3, RELA, TARDBP, CHAMP1, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, RUVBL1, AR, ZNF445, ZBTB16, DMAP1, AHR, FOSL2, HMG20A, MEIS2, SUZ12, RBFOX2, NFIC, ZNF362, PRDM1, MECOM, HDAC3, CDX2, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, MLL, HNF1B, USF2, TCF12, EP300, GATA6, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, TCF25, ZNF639, ARNTL, FEZF1, HES1, TFE3, HBP1, EHF, IRF1, ZGPAT, MRTFB, ZIM3, ATF1, PTBP1, MAFG, SMC1A, CBX1, FIP1L1, ZFX, ZNF534, SMAD3, TWIST1, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, ZNF184, NRF1, PBX4, NR2C1, CHD1, FOS, TGIF2, MED1, CEBPD, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, YY1, ZNF148, SP140, HIF1A, BHLHE22, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, MAZ, MEF2D, BRCA1

Target gene symbol (double-evidenced CRMs): DONSON,GART,AP000295.1,ATP5PO,IFNAR2,SMIM11A,SON,SYNJ1,AP000311.1,PAXBP1,ITSN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000159082, ENSG00000159086, ENSG00000249624, ENSG00000159110, ENSG00000159131, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000205670,

eachgene

Deatailed information for cohesin site CDBP00417304