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Basic information

CohesinDB ID: CDBP00417306

Locus: chr21-33390737-33395496

Data sourse: GSE93080, ENCSR230ZWH, GSE67783, GSE86191, GSE98367, GSE116868, GSE111913, GSE206145, GSE206145-NatGen2015, GSE62063, GSE120943, ENCSR153HNT, GSE111537, GSE50893, GSE126755, ENCSR917QNE

Cell type: RPE, Fibroblast, HCT-116, Monocytes, MB157, GM19240, GM12878, OCI-AML-3, RT-112, K-562, Liver, Neutrophil, HSPC, Macrophage, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 40%, "7_Enh": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, SOX2, NME2, MEIS2, XBP1, FOXA1, PBX2, LYL1, ATF3, NFIC, ZNF362, PRDM1, CBFB, ZNF189, MECOM, PAX5, BACH2, JMJD1C, MAF, TEAD1, TRIM28, RBM39, LMO2, ESR1, MLL, JUN, CTCF, TCF12, EP300, KLF1, PAX8, TRIM24, IRF4, E2F4, TEAD4, KMT2B, GATAD2A, TFAP2C, GLIS1, CHD8, MYCN, POU5F1, RUNX1T1, MTA2, ZBTB17, ZBTB48, ZSCAN5A, STAT1, GATAD1, DDX5, HNF4G, ERG, CHD4, ZNF341, NFKB2, MYC, RAD21, GRHL3, RXRA, GABPA, STAT3, XRCC5, IKZF1, NFE2, NR2F6, VDR, NR3C1, CEBPB, HNRNPL, KMT2A, CREB1, EPAS1, ZNF652, EBF3, ZHX2, SPI1, IRF1, INTS13, GATA2, ZNF644, FLI1, MXI1, MRTFB, ZNF554, RUNX1, BCL6, SMC1A, CEBPA, MAFG, CRY1, SIN3A, ZFX, ZNF770, SMARCC1, TWIST1, MEF2A, RARA, ZNF384, ZNF35, RUNX2, DAXX, ZNF48, PRDM9, PBX3, FOXM1, FOS, CDK8, MED1, TEAD3, MYB, SMAD1, C11orf30, STAT5A, MAFK, SP1, BCL11A, HNF4A, IKZF5, REST, ARID1A, ZBTB7A, TCF3, SMC3, STAG1, MLLT1, SKI, PPARG, FOXA2, EBF1, MEIS1, GTF2B, WT1, MAFF, MEF2C, ZBTB33, CDK9, ZNF580, KDM1A, YY1, RELA, JUNB, AHR, MCM3, SP140, TCF4, HIF1A, ZIC2, OTX2, GATA3, MAX, CEBPG, KLF4, NR2F2, TP53, NFKB1, TBX21, AR, RXR, EGR1, ZBTB26, HSF1, IKZF2, BRD4, JUND, MAZ, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): ATP5PO,DONSON,PAXBP1,AP000295.1,SMIM11A,SON,IFNAR2,GART,ITSN1,SYNJ1,AP000311.1

Function elements

Human SNPs: Rheumatoid_arthritis

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 20

Related genes and loops

Related gene: ENSG00000159082, ENSG00000159086, ENSG00000249624, ENSG00000159110, ENSG00000159131, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000205670,

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Deatailed information for cohesin site CDBP00417306