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Basic information

CohesinDB ID: CDBP00417309

Locus: chr21-33400356-33408549

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, GSE126634, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE25021, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE93080, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE138105, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE94872, GSE118494, ENCSR338DUC, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR981FDC, GSE62063, ENCSR000BMY, ENCSR000EHX, ENCSR620NWG, ENCSR635OSG, ENCSR767DFK, GSE206145, ENCSR495WGO, ENCSR217ELF, GSE55407, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, ENCSR000ECS, GSE38411

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, B-cell, RPE, GM2630, Fibroblast, HEKn, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, Macrophage, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, THP-1, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 44% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.356

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "2_TssAFlnk": 23%, "5_TxWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, PGR, NME2, XBP1, FOXA1, HLF, MLL4, ZFHX2, HDGF, LYL1, ZNF90, NFIC, THAP1, CBFB, ZNF189, MECOM, ZSCAN4, TP63, MITF, JMJD1C, KLF5, ELF1, TRIM28, TEAD1, ETV1, KLF6, LMO2, ESR1, TP73, USF2, JUN, TCF12, CTCF, EP300, RFX5, RAD51, SMC1, TEAD4, TFAP2C, EED, GLIS1, ZSCAN5D, MYCN, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZNF134, ERG2, PAX6, ERG, CHD4, ETS1, MYC, SMARCA4, RAD21, LHX2, RXRA, NKX2-1, STAT3, ZNF614, XRCC5, IKZF1, RCOR1, ARNTL, VDR, NR3C1, CEBPB, STAT5B, KMT2A, EZH2, ZHX2, SPI1, MIXL1, HDAC2, INTS13, GATA2, ZNF644, MXD3, FLI1, RELB, MRTFB, ETV5, RUNX1, BCL6, SMC1A, CEBPA, LDB1, SIN3A, ZFX, SMAD3, ERG3, TWIST1, SMARCC1, ZBTB2, ZNF384, RUNX2, ARNT, DAXX, ZNF48, SMAD4, CBFA2T3, PBX3, ZNF10, FOS, CDK8, MED1, TEAD3, MYB, SCRT2, EVI1, HIF2A, USF1, BCL11A, NIPBL, SP1, REST, ATF7, PHIP, BCOR, TCF3, SMC3, MLLT1, STAG1, SKI, MEF2B, CBX3, MTA3, EBF1, MEIS1, ZNF600, ZSCAN16, WT1, ZBTB33, CDK9, YY1, RELA, NEUROD1, MCM3, HIF1A, OTX2, GATA3, TAL1, MAX, ZNF143, GATA1, PLAG1, GFI1B, NR2F2, TCF7L2, KDM5B, TP53, NFKB1, ELF3, PHF5A, BRD2, TBX21, BHLHE40, AR, TAF1, EGLN2, ZBTB42, HSF1, NCOR1, ZBTB26, BRD4, SCRT1, JUND, MAZ, AHR

Target gene symbol (double-evidenced CRMs): AP000295.1,IFNGR2,SYNJ1,IFNAR2

Function elements

Human SNPs: Rheumatoid_arthritis

Number of somatic mutations (coding): 78

Number of somatic mutations (non-coding): 22

Related genes and loops

Related gene: ENSG00000159082, ENSG00000249624, ENSG00000159110, ENSG00000159128,

eachgene

Deatailed information for cohesin site CDBP00417309