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Basic information

CohesinDB ID: CDBP00417312

Locus: chr21-33417627-33420477

Data sourse: GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE98367, GSE76893, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR000EDE, ENCSR153HNT, ENCSR703TNG, ENCSR000ECS, GSE165895

Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hela-Kyoto, Monocytes, A-549, HeLa-S3, K-562, HSPC, Macrophage, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.867

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 37%, "5_TxWk": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: GLIS1, PGR, SMC1A, PPARG, FOXA2, ZNF778, ID3, ZFX, CTBP1, MEIS2, SIN3A, SMAD3, ZSCAN5A, ZBTB48, FOXA1, ZNF600, GATAD1, SAP130, PBX2, SP4, HOXB13, BCL3, ZFHX2, ERG, YY1, HOXC5, TWIST1, PRPF4, ZNF384, NFIC, OSR2, ZNF184, PBX4, NKX2-1, GATA3, SMAD4, GABPA, MAX, PBX3, AGO2, MITF, ZNF736, MED1, TLE3, NR3C1, PDX1, ELF1, NR2F2, CREB1, TCF7L2, SCRT2, ESR1, PKNOX1, FEZF1, ZNF334, USF2, EGR2, ELF3, RBM22, TCF12, SP1, BAF155, USF1, ARID4B, AR, MNT, SPI1, EP300, REST, BRD4, JUND, FOXP1, GATAD2A, ETV5, RBPJ, FOSL2

Target gene symbol (double-evidenced CRMs): IFNGR2,SYNJ1,AP000295.1,IFNAR2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 30

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159082, ENSG00000249624, ENSG00000159110, ENSG00000159128,

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Deatailed information for cohesin site CDBP00417312