- Basic information
- CohesinDB ID: CDBP00417319
- Locus: chr21-33432435-33436842
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Data sourse: ENCSR230ZWH, ENCSR000BLY, GSE103477, GSE111537, GSE131606, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE67783, GSE86191, GSE101921, GSE135093, GSE206145-NatGen2015, GSE120943, GSE138105, GSE94872, GSE98367, GSE206145, GSE85526, ENCSR000BMY, ENCSR767DFK, GSE55407, GSE38395, ENCSR944ZCT, ENCSR000HPG, GSE111913, GSE155324, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893
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Cell type: MDM, GM10847, GM2610, SLK, GM19240, Liver, HuCC-T1, B-cell, RPE, GM2630, Fibroblast, HEKn, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, SNYDER, Monocytes, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, THP-1, GM19099, Macrophage, GM12892, HCT-116, A-549, HUVEC, HCAEC, GM19238, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 18% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.522
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 47%,
"5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, CBX5, ZSCAN5C, MEIS2, FOXA1, LEO1, PBX2, TFAP4, HDGF, TSC22D4, BMI1, NFIC, ATF3, ZFP64, RUNX3, CHD7, PRDM1, CBFB, ZNF189, SMARCE1, PAX5, BACH2, MAF, KLF5, ELF1, BCLAF1, ZNF121, ETV1, RBM39, SMAD5, ESR1, MLL, TP73, CTCF, TCF12, JUN, EP300, DPF2, SOX4, IRF4, TRIM24, SOX6, RAD51, E2F1, SMC1, TEAD4, KMT2B, GTF2F1, RBPJ, EED, POU2F2, MYCN, POU5F1, TOP2A, ID3, MTA2, ZBTB48, ZSCAN5A, MLLT3, NBN, ARID3A, ERG, HOXC5, CHD4, ZNF597, ZNF341, ETS1, MYC, SMARCA4, ARID1B, RAD21, FOXP2, GRHL3, PHF21A, RXRA, FOXK2, BATF3, GABPA, STAT3, IKZF1, RCOR1, DNMT3B, GFI1, ZNF639, VDR, CD74, NR3C1, CEBPB, KMT2A, CREB1, GRHL2, EBF3, SPI1, EHF, IRF1, GATA2, GATAD2B, FLI1, MXI1, SMARCA5, RELB, MRTFB, NCOA2, ZNF554, ATF1, RUNX1, SMC1A, CEBPA, HDAC1, SIN3A, ZFX, SMAD3, ERG3, TRIM22, SMARCC1, MEF2A, ZBTB2, TAF15, ZNF184, PBX4, BACH1, ARNT, ATF2, ZEB2, HMBOX1, ETV6, FOXM1, PBX3, SUPT5H, FOS, MED1, PML, CEBPD, MYB, SMAD1, ZNF3, EVI1, STAT5A, RBM22, SP1, BCL11A, NIPBL, ARID2, REST, ZNF479, ATF7, ASH2L, HNRNPLL, TCF3, MLLT1, NFATC3, MEF2B, FOXA2, MTA3, CREM, HDAC6, NFATC1, PAF1, EBF1, ZNF600, ZBED1, WT1, E2F8, ZSCAN16, MEF2C, TCF7, CDK9, HOXB13, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, NEUROD1, SP140, TCF4, SKIL, GATA3, BATF, MAX, AGO2, ZNF592, SP7, GFI1B, NR2F2, NR2F1, ZNF687, PKNOX1, TP53, MED, ZNF334, NFKB1, BRD2, TBX21, BHLHE40, AR, TAF1, ZBTB40, ZNF366, RB1, MYNN, NCOR1, IKZF2, BRD4, ILF3, RNF2, JUND, CUX1, MAZ, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): AP000295.1,IFNAR2,IFNGR2,IFNAR1,SYNJ1,TMEM50B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 144
- Number of somatic mutations (non-coding): 48
- Related genes and loops
- Related gene:
ENSG00000159082,
ENSG00000249624,
ENSG00000159110,
ENSG00000142166,
ENSG00000159128,
ENSG00000142188,
- Related loop:
chr21:32650000-32675000~~chr21:33425000-33450000,
chr21:32825000-32850000~~chr21:33425000-33450000,
chr21:32900000-32925000~~chr21:33425000-33450000,
chr21:32925000-32950000~~chr21:33425000-33450000,
chr21:32975000-33000000~~chr21:33425000-33450000,
chr21:33025000-33050000~~chr21:33425000-33450000,
chr21:33175000-33200000~~chr21:33425000-33450000,
chr21:33199071-33200963~~chr21:33434105-33435828,
chr21:33200000-33225000~~chr21:33425000-33450000,
chr21:33214817-33217264~~chr21:33441565-33443170,
chr21:33225000-33250000~~chr21:33425000-33450000,
chr21:33325000-33350000~~chr21:33425000-33450000,