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Basic information

CohesinDB ID: CDBP00417322

Locus: chr21-33440299-33447453

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, GM19099, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 82% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.111

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 62%, "7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ZNF660, PATZ1, FOXA1, PBX2, MLL4, ZNF596, HDGF, TSC22D4, ATF3, INSM2, NFIC, ZFP64, RUNX3, PRDM1, ZBTB44, IKZF3, ATF4, CBFB, ZNF189, PAX5, ZNF467, ZNF629, MYOG, KLF5, ELF1, BCLAF1, ETV1, KLF10, ESR1, MLL, HDAC8, USF2, JUN, TCF12, CTCF, BAF155, KLF1, EP300, DPF2, IRF4, ZNF423, ZNF528, ZNF175, RBPJ, EED, GLIS1, YBX1, POU2F2, ZNF263, TOP2A, ZNF778, CTBP1, MTA2, ZSCAN21, ZBTB17, ZBTB48, STAT1, ZNF317, ZSCAN5A, SRF, NBN, ARID3A, SP4, ERG, ZBTB21, HOXC5, PBX1, ZNF597, ZNF341, ETS1, TSHZ1, RFX1, RAD21, GRHL3, RXRA, NKX2-1, STAT3, XRCC5, IKZF1, RCOR1, ZNF639, NR3C1, CEBPB, KMT2A, CREB1, KLF8, FEZF1, GRHL2, EBF3, MRTFA, ZHX2, SPI1, KLF17, IRF1, GATAD2B, FLI1, HCFC1, RELB, MRTFB, ZNF76, ZNF554, MYF5, ETV5, RUNX1, SMC1A, SIN3A, ZFX, ZNF335, SMAD3, ZNF770, ERG3, TRIM22, ZNF18, PRDM10, ZNF549, MEF2A, NSD2, CREBBP, ZNF35, NOTCH1, GATA4, OSR2, ZNF184, SP3, PBX4, NRF1, ATF2, ZEB2, ETV6, FOXM1, NR2C1, SUPT5H, SP2, FOS, ZNF10, PBX3, MED1, ZEB1, PML, MYB, SMAD1, TAF7, ZNF3, KLF9, ZBTB18, TBX5, STAT5A, RBM22, NIPBL, BCL11A, SP1, ARID2, REST, ATF7, PHIP, TCF3, SMC3, MLLT1, NFATC3, ZNF394, MEF2B, KLF13, FOXA2, MTA3, CREM, EBF1, NFATC1, ZNF600, ZNF692, ZBED1, WT1, ZNF30, ZNF574, MEF2C, HOXB13, BCL3, KLF7, ZNF589, YY1, RELA, TARDBP, JUNB, ZFP36, SKIL, GATA3, BATF, ZNF143, CEBPG, ZNF592, SP7, NEUROG2, TCF7L2, NR2F1, ZNF687, TP53, PKNOX1, ZBTB6, MED, NFKB1, MYOD1, ZSCAN22, BRD2, TBX21, BHLHE40, AR, PTRF, TAF1, ZBTB40, ZNF324, ZBTB42, ZNF366, RB1, EGR1, ZBTB26, IKZF2, BRD4, SCRT1, CUX1, MAZ, ZSCAN23, IRF9, MEF2D, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): IFNAR2,IFNGR2,IFNAR1,AP000295.1,TMEM50B,SYNJ1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 30

Related genes and loops

Related gene: ENSG00000159082, ENSG00000249624, ENSG00000159110, ENSG00000142166, ENSG00000159128, ENSG00000142188,

eachgene

Deatailed information for cohesin site CDBP00417322