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Basic information

CohesinDB ID: CDBP00417326

Locus: chr21-33451723-33452456

Data sourse: GSE116344, GSE68388, GSE165895

Cell type: RH4, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 50%, "4_Tx": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, HMG20A, PATZ1, FOXA1, RXRB, LEO1, TFAP4, ATF3, THRB, ZFP64, PRDM1, IKZF3, ATF4, PAX5, ZNF629, KLF5, TEAD1, ZNF26, ETV1, ESR1, CTCF, JUN, BAF155, EP300, ZBTB20, GATA6, SOX5, SOX4, ZNF528, ZNF350, FOXA3, GATAD2A, GLIS1, ZNF425, POU5F1, ZNF263, ZSCAN21, ZBTB17, ZBTB48, DUX4, STAT1, SAP130, SP4, TBP, ERG, HOXC5, ZBTB8A, NKX2-1, XRCC5, NR3C1, CEBPB, FEZF1, GRHL2, KLF17, ETV5, SMC1A, BCL6, ZNF335, ZFX, SOX13, SMAD3, ZNF770, ERG3, ZNF549, PRDM10, RARA, ZNF384, ZNF35, GATA4, OSR2, ZNF184, PBX4, ZEB2, SMAD4, PBX3, SUPT5H, FOS, MED1, TEAD3, SCRT2, RBM22, BCL11A, IKZF5, HOXA9, PHIP, PRDM6, FOXA2, ZNF600, ZNF692, WT1, TCF7, HOXB13, KDM1A, RELA, JUNB, GATA3, MAX, GATA1, TLE3, CEBPG, ZFP69B, SP7, TP53, PKNOX1, ZBTB6, ZSCAN22, ELF3, ARID4B, AR, ZNF324, ZBTB42, SCRT1, BRD4, JUND, FOSL2

Target gene symbol (double-evidenced CRMs): AP000295.1,IFNAR1,TMEM50B,SYNJ1,IFNAR2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000159082, ENSG00000249624, ENSG00000159110, ENSG00000142166, ENSG00000142188,

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Deatailed information for cohesin site CDBP00417326