- Basic information
- CohesinDB ID: CDBP00417343
- Locus: chr21-33490969-33492642
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, GSE126634, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE25021, GSE108869, ENCSR000EDW, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000DZP, GSE67783, GSE122299, GSE86191, GSE138405, GSE51234, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE112028, ENCSR703TNG, GSE106870, GSE116344, GSE94872, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000EHW, GSE206145, GSE62063, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE126755, ENCSR000ECS, GSE38411
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Cell type: RH4, CVI-hiPSC, Liver, GP5d, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, BCBL-1, K-562, HFFc6, H1-hESC, Monocytes, MB157, GM12878, SK-N-SH, RT-112, HeLa-Tet-On, HAP1, Macrophage, Ramos, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 16% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.622
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"1_TssA": 30%,
"2_TssAFlnk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, ZBTB44, MORC2, PAX5, ZNF320, SFPQ, TEAD1, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, SOX5, DEK, E2F4, ZNF674, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, BRD3, ZNF263, CTBP1, ZMYND11, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, FOXK2, ZNF8, RCOR1, NR2F6, DACH1, CEBPB, HNRNPL, CREB1, DDX21, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, MXD3, FLI1, HCFC1, DRAP1, MXI1, NR2C2, ZNF785, RELB, EP400, RUNX1, HDAC1, CEBPA, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, SMAD1, C11orf30, EVI1, MBD1, ARID2, IKZF5, AFF1, MBD2, NFATC3, ZNF207, CBX3, CREM, CHD2, PAF1, WT1, MEF2C, CREB3L1, DEAF1, NEUROD1, JUNB, TCF4, BATF, MAF1, PLAG1, ZFP69B, BCL11B, ZBTB6, EGR2, ELF3, ARID4B, ZBTB26, HSF1, ILF3, ZNF316, ZNF660, KDM4B, ZNF101, PBX2, HNRNPK, ATF3, THRB, ZFP64, CDC5L, ZNF467, INTS11, ELF1, RBM39, KLF10, SMAD5, CTCF, JUN, ZBTB20, LMO1, MNT, DPF2, SIX5, IRF4, MLX, TFAP2C, RBPJ, ZNF317, ZBTB17, ZBTB48, ZSCAN21, MTA2, NONO, SRF, NBN, ZNF2, HOMEZ, KDM4A, FOXP2, RXRA, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, NFIL3, THAP11, SOX13, ZNF770, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, NFIB, ZNF48, HMBOX1, ZEB2, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, KLF9, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, MLLT1, ZNF394, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, KLF7, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, ZNF143, AGO2, ZNF141, TP53, ZNF334, ZSCAN22, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, ZNF468, PGR, PATZ1, TFAP4, SIN3B, CHD7, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, SAP30, ESR1, ZNF524, KLF1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ASH1L, ZSCAN5A, ERG2, SP4, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, ZNF24, KLF12, NKX2-1, MCRS1, GABPA, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF384, NFYC, ZNF35, TAF15, SMAD4, ZNF518A, ZEB1, NCOA1, SREBF2, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, ZNF34, PPARG, ZNF692, ZNF30, ZNF574, RELA, TARDBP, SKIL, MAX, GFI1B, TCF7L2, NR2F1, KDM5B, PKNOX1, AR, YAP1, ZNF324, AHR, DMAP1, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, NFIC, ZNF362, PRDM1, KLF14, MECOM, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, USF2, TCF12, EP300, BAF155, PRDM4, E2F1, TEAD4, FOXA3, ZNF175, MYCN, RUNX1T1, ID3, GATAD1, GMEB2, ARID3A, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, ZNF639, FEZF1, TFE3, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, MAFG, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, TWIST1, IRF2, OSR2, ZNF184, NRF1, NR2C1, CHD1, FOS, SUPT5H, MED1, CEBPD, MYB, SCRT2, ZNF558, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, HOXB13, YY1, ZNF148, ZNF610, SP140, OTX2, GATA1, CEBPG, SP7, NR2F2, ZNF843, NFKBIZ, BHLHE40, TAF1, ZBTB40, NOTCH3, CLOCK, MAZ, BRCA1
- Target gene symbol (double-evidenced CRMs): TMEM50B,DNAJC28
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 2
- Number of somatic mutations (non-coding): 7
- Related genes and loops