- Basic information
- CohesinDB ID: CDBP00417353
- Locus: chr21-33510139-33511457
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Data sourse: GSE67783, ENCSR153HNT, GSE86191, GSE98367
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Cell type: K-562, HCT-116, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"4_Tx": 78%,
"5_TxWk": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MEIS2, FOXA1, LEO1, PBX2, BMI1, NFIC, NFE2L2, JUN, TCF12, CTCF, EP300, MNT, DPF2, TRIM24, SOX6, E2F1, ZNF528, TEAD4, ZNF239, POU5F1, CTBP1, MTA2, ZSCAN21, ZBTB48, ZSCAN5A, NONO, ARID3A, MYC, SMARCA4, RFX1, ARID1B, GRHL3, FOXK2, IKZF1, RCOR1, KMT2A, HDAC2, GATA2, MXI1, SMC1A, HDAC1, SIN3A, ZFX, ZMIZ1, ZNF184, CBFA2T3, PBX3, SUPT5H, PML, CEBPD, SMAD1, SETDB1, STAT5A, KLF16, RBM22, USF1, BCL11A, ZBTB7A, ZNF479, ATF7, MLLT1, TRP47, CBFA2T2, CREM, PAF1, NFATC1, ZBTB33, BCL3, RELA, JUNB, NEUROD1, SP140, ZFP36, TAL1, MAX, GATA1, ZNF592, GFI1B, NR2F2, TP53, PKNOX1, BHLHE40, PAX3-FOXO1, MYNN, RNF2, NCOR1, JUND, ILF3, MAZ, ZZZ3, ZNF24
- Target gene symbol (double-evidenced CRMs): IFNGR2,AP000311.1,CRYZL1,URB1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 99
- Number of somatic mutations (non-coding): 32
- Related genes and loops
- Related gene:
ENSG00000142207,
ENSG00000159128,
ENSG00000249209,
ENSG00000205758,
- Related loop:
chr21:29050000-29075000~~chr21:33500000-33525000,
chr21:32325000-32350000~~chr21:33500000-33525000,
chr21:32375000-32400000~~chr21:33500000-33525000,
chr21:33375000-33400000~~chr21:33500000-33525000,
chr21:33500000-33525000~~chr21:33600000-33625000,
chr21:33500000-33525000~~chr21:37150000-37175000,