Deatailed information for cohesin site CDBP00417388

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  • Basic information
  • CohesinDB ID: CDBP00417388
  • Locus: chr21-33586625-33587297
  • Data sourse: GSE116344, ENCSR153HNT
  • Cell type: K-562, RH4
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 1% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.978
  • Subunit: SA1,Rad21
  • CTCF binding site: non-CTCF CTCF motif: False
  • Genomic location: TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: non-Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 88% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): False
  • Chromatin annotation: "5_TxWk": 49%, "7_Enh": 16%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF675, FOXA1, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ARID5B, ZNF157, SOX5, PAX8, E2F4, ZNF674, DEK, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, ZMYND11, STAT1, SAP130, ERG, PAX6, ZBTB21, ZBTB8A, EZH1, SMARCA4, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, HCFC1, MXI1, RELB, EP400, RUVBL2, RUNX1, HDAC1, NKX2-2, CEBPA, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ZBTB10, ATF2, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, GSPT2, ARID2, IKZF5, RBM25, MBD2, ELL2, HMGB1, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, CHD2, PAF1, NFATC1, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, BATF, MAF1, PLAG1, ZFP69B, BCL11B, KLF4, MED, EGR2, RBM14, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, SRSF4, ZNF596, HNRNPK, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, CBFB, ZNF273, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, CTCF, TAF3, L3MBTL4, ZBTB20, MNT, LMO1, DPF2, RYBP, IRF4, ZNF423, PDX1, TFAP2C, MLX, RBPJ, ZNF317, ZBTB17, ZBTB48, ZSCAN21, MTA2, NONO, SRF, DDX5, NBN, ZKSCAN2, ZNF2, KDM4A, FOXP2, HOMEZ, RXRA, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZSCAN29, SMARCA5, NFIL3, THAP11, LDB1, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZNF770, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, BACH1, DAXX, ZNF48, PRDM9, ZEB2, NFYA, PBX3, NCAPH2, MAFB, ZNF10, HMGXB4, TEAD3, ZXDB, ZNF680, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, NKX2-5, ATF7, ASH2L, CTBP2, GLIS2, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, KLF7, KDM1A, ZKSCAN1, ZNF266, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, NFKB1, ZSCAN22, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, BRD4, CUX1, ZSCAN23, IRF9, PGR, SOX2, PATZ1, LEO1, UBTF, RING1B, TFAP4, SIN3B, SETX, CHD7, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ZNF217, ESR1, ZNF524, KLF1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, PHF21A, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, ZNF182, GATAD2B, ZNF76, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF384, CREBBP, NFYC, TAF15, ZNF518A, SMAD4, CBFA2T3, CDK8, CSNK2A1, ZEB1, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PTTG1, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, KMT2D, YAP1, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, ZNF391, HMG20A, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, SFMBT1, ZFHX2, NFIC, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, RCOR2, MLL, TCF12, BAF155, EP300, GATA6, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, MLLT3, GATAD1, GMEB2, ARID3A, ZNF300, ASCL1, MIER1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, ZNF664, HBP1, TFE3, IRF1, EHF, SREBF1, ZGPAT, NAB2, MRTFB, ZC3H11A, MYF5, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, ZSCAN30, ZNF184, SMAD2, OSR2, NRF1, PBX4, SUPT5H, FOS, CHD1, MED1, KDM6B, MYB, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, BRCA1, SP140, HIF1A, OTX2, ZNF519, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): ATP5PO,CRYZL1,IFNAR2,ITSN1,SMIM11A,AP000295.1,AP000311.1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 20
  • Number of somatic mutations (non-coding): 4
  • Related genes and loops
  • Related gene: ENSG00000249624, ENSG00000159110, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000205670,
  • Related loop: chr21:33200000-33225000~~chr21:33575000-33600000, chr21:33575000-33600000~~chr21:33675000-33700000, chr21:33575000-33600000~~chr21:33700000-33725000, chr21:33575000-33600000~~chr21:33875000-33900000, chr21:33575000-33600000~~chr21:33900000-33925000, chr21:33575000-33600000~~chr21:34350000-34375000, chr21:33587403-33589803~~chr21:33893900-33896299, chr21:33587502-33589829~~chr21:33893790-33895862,
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