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Basic information

CohesinDB ID: CDBP00417430

Locus: chr21-33678520-33679233

Data sourse: GSE206145-GSE177045, GSE138405, GSE68388, GSE126990, GSE108869

Cell type: MCF-7, HeLa-S3, Hela-Kyoto, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: Mau2,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 51%, "5_TxWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, PATZ1, FOXA1, BMI1, NFIC, ATF3, ZFP64, ZNF362, RUNX3, ZBTB44, ATF4, MZF1, ZNF629, KLF5, TRIM28, LMO2, ESR1, CTCF, BAF155, KLF1, ZNF695, ZBTB20, PAX8, DPF2, TRIM24, SOX6, ZNF280A, PDX1, TFAP2C, GLIS1, NANOG, POU5F1, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ERG, ZBTB21, ZNF341, MYC, SMARCA4, ARID1B, NKX2-1, STAT3, NKX3-1, IKZF1, RCOR1, ZNF639, VDR, NR3C1, CEBPB, ESRRA, CREB1, KLF8, FEZF1, ZHX2, GATA2, ZNF182, ZNF766, NFIL3, ZNF554, RUNX1, HDAC1, NKX2-2, SMAD3, CBX8, ERG3, ZNF18, PRDM10, ZNF384, RUNX2, GATA4, OSR2, ZNF184, PBX4, ARNT, ATF2, PRDM9, ZEB2, ZNF680, PIAS1, KLF9, RBM22, BCL11A, SP1, ARID1A, ATF7, PHIP, FOXP1, PRDM6, SMC3, ZNF394, FOXA2, ZNF600, ZNF692, ZSCAN16, WT1, ZNF30, HOXB13, YY1, RELA, AHR, ZFP36, HIF1A, OTX2, GATA3, TLE3, KLF4, CEBPG, SP7, GFI1B, TP53, EGR2, BRD2, ELF3, AR, ZBTB40, ZNF324, EGLN2, ZNF366, ZBTB26, RNF2, MYNN, BRD4, JUND, ZFP42, ZNF316

Target gene symbol (double-evidenced CRMs): DONSON,MRPS6,AP000311.1,SLC5A3,RCAN1,CLIC6,ITSN1,GART,CRYZL1,ATP5PO,SON,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 63

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159131, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159212,

eachgene

Deatailed information for cohesin site CDBP00417430