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Basic information

CohesinDB ID: CDBP00417432

Locus: chr21-33682198-33684451

Data sourse: GSE104888, ENCSR000BSB, ENCSR501LQA, ENCSR000BLY, ENCSR000ECS, GSE108869, GSE165895, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE138105, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR193NSH, ENCSR879KXD, GSE206145, GSE85526, ENCSR981FDC, ENCSR620NWG, ENCSR984DZW, ENCSR495WGO, GSE105004, ENCSR853VWZ, ENCSR956LGB, GSE129526, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE68388, GSE126990, ENCSR748MVX, GSE73207

Cell type: SLK, HuCC-T1, RPE, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, TF-1, SK-N-SH, Hela-Kyoto, HCT-116, HEK293T, A-549, HUVEC, HCAEC, HeLa, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 16% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.756

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 33%, "5_TxWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SMARCA2, HMG20A, E2F7, ZNF660, SOX2, MEIS2, PATZ1, FOXA1, PBX2, RXRB, TFAP4, ATF3, NFIC, ZFP64, ZNF362, CHD7, PRDM1, IKZF3, MORC2, ZNF273, ZNF189, SMARCE1, PAX5, MZF1, TP63, MITF, ZNF467, ZNF629, KLF5, TEAD1, TRIM28, ZNF121, KLF6, SNAI2, NFE2L2, KLF10, RCOR2, ESR1, HNF1B, TP73, MLL, ZBTB49, JUN, TCF12, CTCF, EP300, ZNF695, MNT, GATA6, SOX5, DPF2, SOX4, IRF4, SOX6, E2F1, ZNF528, SMC1, ZNF350, TEAD4, KLF3, FOXA3, ZNF175, GTF2F1, EHMT2, PDX1, GATAD2A, MLX, GLIS1, RBPJ, NANOG, CHD8, POU2F2, MYCN, POU5F1, BRD3, ID3, TOP2A, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZNF317, ZNF134, SRF, SAP130, GATAD1, ARID3A, HNF4G, PAX6, ZBTB21, HOXC5, ERG, PRDM9, NFKB2, ZNF341, MYC, SMARCA4, RFX1, ARID1B, RAD21, EOMES, LHX2, HOMEZ, RXRA, NKX2-1, FOXK2, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, IKZF1, RCOR1, MIER3, DACH1, ZNF639, VDR, NR2F6, NR3C1, CEBPB, ZNF750, ESRRA, CREB1, TBL1XR1, KLF8, GRHL2, FEZF1, EBF3, ZHX2, ZKSCAN5, SPI1, MIXL1, EHF, IRF1, KLF17, HDAC2, GATA2, ZNF644, SIX2, FLI1, DRAP1, MXI1, ZGPAT, ZNF766, HEXIM1-CDK9, MRTFB, NFIL3, ZNF554, ATF1, ETV5, THAP11, ZNF585A, MAFG, SMC1A, HDAC1, BCL6, NKX2-2, CEBPA, AFF4, ZFX, SOX13, SIN3A, EZH2phosphoT487, SMAD3, ZBTB12, CBX8, TWIST1, SMARCC1, PRDM10, ZNF18, RARA, ZNF35, ZNF384, PRPF4, NFYC, RUNX2, GATA4, OSR2, ZNF184, PBX4, DAXX, ARNT, ATF2, SMAD4, HMBOX1, ZEB2, NFYA, CBFA2T3, PBX3, ZNF10, FOS, CDK8, CHD1, FOXM1, SMARCB1, MED1, ZEB1, PML, ZXDB, TEAD3, MYB, NR1H2, C11orf30, TBX5, NUP98-HOXA9, MAFK, NIPBL, BCL11A, SP1, USF1, HNF4A, NKX2-5, REST, ARID1A, ZBTB7A, ZHX1, ASH2L, ZNF605, HOXA9, PHIP, FOXP1, PRDM6, SMC3, ELL2, NCOR2, STAG2, CBFA2T2, PPARG, FOXA2, CBX3, CREM, CHD2, PAF1, ZNF207, ZNF600, ZNF692, GTF2B, MAFF, ZNF30, WT1, ESR2, ZSCAN16, ZNF574, ZBTB33, TCF7, CDK9, BCL3, ZNF318, KDM1A, YY1, RELA, JUNB, ISL1, ZNF830, ZFP36, TCF4, OTX2, GATA3, TAL1, MAX, SPIB, GATA1, ZNF143, MTA1, HAND2, KLF4, CEBPG, SP7, GFI1B, ZFP69B, NR2F2, ZNF512, NR2F1, TCF7L2, TP53, PKNOX1, ZNF334, NFKB1, ZSCAN22, MYOD1, ELF3, BRD2, T, KAT8, BHLHE40, AR, ARID4B, TAF1, NFKBIZ, YAP1, ZNF324, ZNF366, ZBTB42, HSF1, RNF2, MYNN, BRD4, JUND, ILF3, ZBTB26, ELF1, ZSCAN23, ZNF24, FOSL2

Target gene symbol (double-evidenced CRMs): SLC5A3,GART,SON,RCAN1,ATP5PO,ITSN1,AP000311.1,CLIC6,CRYZL1,DONSON,SMIM11A,MRPS6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 126

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159131, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159212,

eachgene

Deatailed information for cohesin site CDBP00417432