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Basic information

CohesinDB ID: CDBP00417434

Locus: chr21-33687051-33688043

Data sourse: GSE72082, GSE138405, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT, ENCSR000EDW

Cell type: K-562, Hela-Kyoto, Fibroblast, Hep-G2

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2,Mau2,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 34%, "7_Enh": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, HMG20A, SOX2, FOXA1, RXRB, KDM3A, TFAP4, NFIC, ZFP64, ZNF362, MXD4, CDX2, TEAD1, KLF6, RCOR2, ESR1, JUN, EP300, BAF155, L3MBTL4, SOX5, GATA6, TEAD4, FOXA3, ZNF175, GATAD2A, MLX, RBPJ, NANOG, POU5F1, BRD3, HHEX, GATAD1, SAP130, ARID3A, ERG, ETS1, MYC, SMARCA4, HOMEZ, ARID1B, RXRA, FOXK2, GABPA, ZNF614, NKX3-1, MIER3, NR2F6, NR3C1, CEBPB, CREB1, TBL1XR1, EBF3, MIXL1, TFE3, HDAC2, GATA2, ZGPAT, NFIL3, MRTFB, THAP11, BCL6, CEBPA, SOX13, ZFX, TBX3, CBX8, SP5, SMARCC1, MYBL2, RARA, ZNF384, CREBBP, GATA4, SMAD4, FOS, TEAD3, PIAS1, RBM22, MAFK, BCL11A, HNF4A, ARID2, REST, ZBTB7A, ASH2L, PHIP, FOXP1, ETV4, SKI, PPARG, FOXA2, CREM, EBF1, MAFF, TCF7, HOXB13, KDM1A, BRG1, TAL1, TLE3, CEBPG, NR2F2, TCF7L2, ELF3, KAT8, ARID4B, AR, BHLHE40, RNF2, NCOR1, JUND, BRD4, NOTCH3, ZNF24, FOSL2

Target gene symbol (double-evidenced CRMs): RCAN1,CLIC6,SLC5A3,SMIM11A,SON,AP000311.1,ITSN1,DONSON,MRPS6,CRYZL1,ATP5PO,GART

Function elements

Human SNPs: .

Number of somatic mutations (coding): 63

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159131, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159212,

eachgene

Deatailed information for cohesin site CDBP00417434