- Basic information
- CohesinDB ID: CDBP00417445
- Locus: chr21-33705365-33705686
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Data sourse: GSE206145-NatGen2015, GSE67783
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Cell type: Fibroblast, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 0% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: SA1,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 76%,
"5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PGR, XBP1, FOXA1, UBTF, THAP1, PRDM1, ZNF189, TP63, ZNF320, TEAD1, TRIM28, ESR1, OCA2, CTCF, SMC1, GATAD2A, TFAP2C, EED, GLIS1, CHD8, ZSCAN5D, POU5F1, ZBTB48, DDX5, TBP, ERG, ETS1, MYC, RAD21, GABPA, APC, XRCC5, STAT3, CREB1, EZH2, IRF1, ZNF182, ZIM3, ETV5, RUNX1, ZNF585A, BCL6, HDAC1, NKX2-2, POU4F2, SMAD3, CBX8, ERG3, ZNF133, RUNX2, ARNT, HMBOX1, MAFB, TEAD3, NCOA1, RBM22, BCL11A, ASH2L, FOXP1, ELL2, TRP47, PPARG, FOXA2, TBL1X, ZSCAN16, WT1, HOXB13, YY1, RELA, SP140, HIF1A, OTX2, ZNF143, GATA1, KDM5B, TP53, PHOX2B, ELF3, AR, EGLN2, ZBTB26, NOTCH3, BRD4, AHR
- Target gene symbol (double-evidenced CRMs): DONSON,HUNK,MRPS6,SLC5A3,RCAN1,ATP5PO,AP000311.1,SON,CRYZL1,ITSN1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 27
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000142149,
ENSG00000159140,
ENSG00000159147,
ENSG00000249209,
ENSG00000205758,
ENSG00000205726,
ENSG00000241837,
ENSG00000243927,
ENSG00000198743,
ENSG00000159200,
- Related loop:
chr21:31950000-31975000~~chr21:33700000-33725000,
chr21:33550000-33575000~~chr21:33700000-33725000,
chr21:33575000-33600000~~chr21:33700000-33725000,
chr21:33700000-33725000~~chr21:33875000-33900000,
chr21:33700000-33725000~~chr21:33900000-33925000,
chr21:33700000-33725000~~chr21:34100000-34125000,
chr21:33700000-33725000~~chr21:34200000-34225000,
chr21:33700000-33725000~~chr21:34250000-34275000,
chr21:33700000-33725000~~chr21:34325000-34350000,
chr21:33700000-33725000~~chr21:34525000-34550000,
chr21:33700000-33725000~~chr21:34600000-34625000,