- Basic information
- CohesinDB ID: CDBP00417474
- Locus: chr21-33768415-33770555
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Data sourse: GSE86191, GSE138405, GSE206145, GSE101921, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EDE, GSE116344
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Cell type: RPE, Hela-Kyoto, Fibroblast, HCT-116, RH4, HCAEC, HeLa-S3, K-562
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 47%,
"4_Tx": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, ZFX, ZNF317, SMAD3, FOXA1, SRF, HOXB13, SMARCC1, RELA, JUNB, MYC, SMARCA4, CHD7, RAD21, GRHL3, GATA3, TAL1, STAT3, RCOR1, NR3C1, CEBPB, TEAD1, JUN, CTCF, TCF12, SPI1, AR, GATA6, GATA2, YAP1, IRF4, ZHX1, FLI1, BRD4, JUND, SMC1, MRTFB, TEAD4
- Target gene symbol (double-evidenced CRMs): ATP5PO,ITSN1,AP000311.1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 132
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000249209,
ENSG00000205726,
ENSG00000241837,
- Related loop:
chr21:33650000-33675000~~chr21:33750000-33775000,
chr21:33675000-33700000~~chr21:33775000-33800000,
chr21:33750000-33775000~~chr21:33875000-33900000,
chr21:33750000-33775000~~chr21:33900000-33925000,
chr21:33775000-33800000~~chr21:33875000-33900000,
chr21:33775000-33800000~~chr21:34100000-34125000,
chr21:33775000-33800000~~chr21:34250000-34275000,