- Basic information
- CohesinDB ID: CDBP00417490
- Locus: chr21-33800835-33802884
-
Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR150EFU, ENCSR000ECS, GSE25021, GSE108869, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE67783, GSE86191, GSE138405, GSE101921, GSE138105, ENCSR703TNG, GSE116344, ENCSR895JMI, GSE98367, ENCSR193NSH, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR620NWG, ENCSR495WGO, ENCSR000BTQ, ENCSR853VWZ, GSE131956, GSE129526, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE68388, GSE83726, GSE126990, ENCSR748MVX
-
Cell type: RH4, SLK, Liver, HuCC-T1, RPE, HMEC, Ishikawa, HeLa-S3, IMR-90, HFFc6, MB157, GBM39, RT-112, Macrophage, MCF-7, Hela-Kyoto, HCT-116, HEK293T, A-549, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 17% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.778
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 53%,
"7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SMARCA2, ZNF660, ZSCAN5C, SOX2, XBP1, PATZ1, FOXA1, ZNF101, TFAP4, ATF3, INSM2, ZBTB44, CHD7, IKZF3, ZNF189, SMARCE1, TP63, ZNF629, KLF5, TEAD1, TRIM28, ELF1, KLF6, SNAI2, NFE2L2, KLF10, LMO2, ZNF217, HNF1B, TP73, ESR1, ETV1, USF2, ZNF561, JUN, TCF12, CTCF, BAF155, EP300, ZNF695, MNT, LMO1, ZNF577, KLF1, DPF2, SOX4, PRDM4, IRF4, RFX5, DEK, E2F4, E2F1, ZNF528, SMC1, PDX1, RBPJ, TFAP2C, GLIS1, NANOG, CHD8, POU5F1, ZNF778, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZNF317, STAT1, ZNF134, GATAD1, SP4, TBP, HNF4G, HOXC5, ZBTB21, ERG, USP7, ASCL1, ONECUT1, MYC, SMARCA4, TSHZ1, RAD21, FOXP2, GRHL3, RXRA, NKX2-1, GABPA, STAT3, UBN1, NKX3-1, RCOR1, NFE2, ZNF639, ZNF750, NR3C1, ESRRA, CEBPB, KMT2A, CREB1, FOXK1, KLF8, FEZF1, GRHL2, TRPS1, ZHX2, SPI1, EHF, IRF1, KLF17, HDAC2, GATA2, SIX2, FLI1, MXI1, ZNF766, MRTFB, ZIM3, ZNF554, RUNX1, SMC1A, CBX1, CEBPA, NKX2-2, SIN3A, ZFX, POU4F2, AFF4, SMAD3, REPIN1, ZNF770, CBX8, ERG3, ZNF18, PRDM10, ZNF549, SMARCC1, CREBBP, ZNF384, ZNF35, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, GR, PBX4, ARNT, NRF1, DAXX, ZNF518A, ZEB2, PBX3, FOXM1, ZNF10, FOS, CDK8, MED1, ZEB1, SPDEF, ZXDB, MYB, SCRT2, PIAS1, ZNF558, KLF9, EVI1, SP1, NIPBL, BCL11A, HNF4A, TFAP2A, REST, ARID1A, ZHX1, ATF7, ASH2L, PHIP, TCF3, FOXP1, MBD2, PRDM6, SMC3, ELL2, ZNF34, STAG1, ZNF394, PPARG, FOXA2, CBX3, CHD2, ZNF600, ZNF692, ZSCAN16, WT1, ZNF30, MAFF, ZNF574, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, NEUROD1, ZNF610, ZIC2, HIF1A, TCF4, OTX2, GATA3, TAL1, MAX, ZNF449, ZNF143, TLE3, KLF4, ZFP69B, SP7, NR2F2, TCF7L2, NEUROG2, KDM5B, TP53, PKNOX1, ZBTB6, ZSCAN22, NFKB1, MYOD1, ELF3, ZNF843, BRD2, BHLHE40, AR, TAF1, ZNF324, EGLN2, ZNF366, ZBTB42, RNF2, BRD4, SCRT1, JUND, MAZ, ZSCAN23, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): CRYZL1,DONSON,AP000295.1,AP000311.1,IFNAR2,SON,ITSN1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 242
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000249624,
ENSG00000159110,
ENSG00000159140,
ENSG00000159147,
ENSG00000249209,
ENSG00000205758,
ENSG00000205726,
- Related loop:
chr21:33200000-33225000~~chr21:33800000-33825000,
chr21:33550000-33575000~~chr21:33800000-33825000,
chr21:33625000-33650000~~chr21:33800000-33825000,
chr21:33640623-33644540~~chr21:33801019-33802509,
chr21:33675000-33700000~~chr21:33775000-33800000,
chr21:33675000-33700000~~chr21:33800000-33825000,
chr21:33775000-33800000~~chr21:33875000-33900000,
chr21:33775000-33800000~~chr21:34100000-34125000,
chr21:33775000-33800000~~chr21:34250000-34275000,