- Basic information
- CohesinDB ID: CDBP00417499
- Locus: chr21-33819690-33821242
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Data sourse: GSE67783, GSE86191, GSE126634, GSE111913, GSE206145, GSE152721, GSE206145-NatGen2015
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Cell type: RPE, Fibroblast, HCT-116, HSPC, RT-112, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 52%,
"4_Tx": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, HMG20A, ZSCAN5C, SOX2, XBP1, FOXA1, PBX2, ZBTB44, ZNF322, IKZF3, PRDM1, CHD7, ZNF189, MITF, TRIM28, ESR1, OCA2, USF2, ZNF561, JUN, CTCF, TEAD4, KLF3, PDX1, RBPJ, TFAP2C, GLIS1, CHD8, ZNF263, TOP2A, ZNF778, ZNF317, ZBTB17, ZBTB48, SRF, SP4, HNF4G, OGG1, MYC, SMARCA4, GRHL3, XRCC5, SOX10, CEBPB, FEZF1, HDAC2, GATA2, ZNF644, CEBPA, ZNF335, ZFX, SOX13, ZBTB12, TET2, RARA, ZNF384, GATA4, OSR2, DAXX, ATF2, SMAD4, FOXM1, MED1, ZXDB, SCRT2, NUP98-HOXA9, RBM22, USF1, PHIP, PRDM6, SMC3, ELL2, PPARG, FOXA2, TBL1X, ZNF692, WT1, ESR2, YY1, RELA, ZIC2, HIF1A, GATA1, PLAG1, SP7, NR2F2, NR2F1, KDM5B, PKNOX1, BRD2, BHLHE40, AR, ZNF324, ZNF366, BRD4, SCRT1, AHR
- Target gene symbol (double-evidenced CRMs): AP000311.1,SON,ITSN1,AP000295.1,CRYZL1,IFNAR2,DONSON
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 10
- Number of somatic mutations (non-coding): 1
- Related genes and loops
- Related gene:
ENSG00000249624,
ENSG00000159110,
ENSG00000159140,
ENSG00000159147,
ENSG00000249209,
ENSG00000205758,
ENSG00000205726,
- Related loop:
chr21:33200000-33225000~~chr21:33800000-33825000,
chr21:33550000-33575000~~chr21:33800000-33825000,
chr21:33625000-33650000~~chr21:33800000-33825000,
chr21:33625000-33650000~~chr21:33825000-33850000,
chr21:33675000-33700000~~chr21:33800000-33825000,
chr21:33825000-33850000~~chr21:38075000-38100000,
chr21:7800000-7825000~~chr21:33825000-33850000,