- Basic information
- CohesinDB ID: CDBP00417515
- Locus: chr21-33853175-33856045
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE131606, GSE25021, GSE93080, ENCSR000EAC, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR000EEG, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, GSE55407, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE131577
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Cell type: MDM, RH4, GM2610, GM19240, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, K-562, GM18526, H1-hESC, GM12878, GM12891, GM2588, SK-N-SH, RT-112, THP-1, GM19099, Macrophage, MCF-7, GM12892, Hela-Kyoto, HCT-116, HL-60, Hep-G2, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 17% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.689
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 49%,
"5_TxWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, CBX5, HMG20A, SOX2, MEIS2, XBP1, FOXA1, SUZ12, RXRB, PBX2, ATF3, THRB, BMI1, THAP1, CTCFL, CHD7, PRDM1, ZNF189, SMARCE1, TP63, MZF1, MITF, ZNF320, MYOG, TEAD1, TRIM28, ELF1, RBM39, NFE2L2, RCOR2, ESR1, OCA2, CTCF, JUN, TCF12, BAF155, SOX5, DPF2, SOX4, TRIM24, TEAD4, FOXA3, GATAD2A, TFAP2C, EED, RBPJ, GLIS1, MLX, POU2F2, NANOG, BRD1, MYCN, ZNF263, TOP2A, ID3, POU5F1, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ZNF134, ERG, ZNF585B, ETS1, MYC, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, ZNF197, STAT3, XRCC5, ZNF614, PRDM14, IKZF1, NFE2, RCOR1, NR2F6, MIER3, DNMT3B, NR3C1, ESRRA, ZNF750, CEBPB, CREB1, EZH2, GRHL2, EBF3, GABPB1, TFE3, HDAC2, GATA2, ZNF644, DRAP1, ZGPAT, NFIL3, NCOA2, ZNF554, MYF5, ETV5, RUNX1, THAP11, BCL6, CBX1, CEBPA, SMC1A, SIN3A, ZNF534, ZFX, AFF4, SMAD3, TET2, CBX8, PRDM10, CREBBP, RARA, ZBTB2, CDK6, GATA4, ARNT, PBX4, DAXX, ZNF48, PRDM9, SMAD4, CBFA2T3, ZNF10, FOS, CDK8, CHD1, MED1, TEAD3, SCRT2, PIAS1, ZNF680, ZMYM3, ZNF3, SETDB1, EVI1, KLF16, MAFK, USF1, TFAP2A, HNF4A, IKZF5, REST, ZBTB7A, RBM25, ASH2L, CTBP2, MBD2, BCOR, AATF, SMC3, ELL2, STAG1, ZNF394, TRP47, CBFA2T2, ZNF316, FOXA2, MTA3, CBX3, EBF1, ZNF600, WT1, MAFF, ESR2, CDK9, HOXB13, ZKSCAN1, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, NEUROD1, MCM3, SP140, ZFP36, HIF1A, ZIC2, OTX2, GATA3, TAL1, MAX, NRIP1, ZNF143, ZNF449, HAND2, CBX2, PLAG1, CEBPG, SP7, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, NEUROG2, TP53, NFKB1, MYOD1, T, KAT8, BHLHE40, AR, ARID4B, ZNF366, HEXIM1, HSF1, ZBTB26, BRD4, JUND, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): CRYZL1,AP000311.1,ITSN1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 68
- Number of somatic mutations (non-coding): 13
- Related genes and loops
- Related gene:
ENSG00000249209,
ENSG00000205758,
ENSG00000205726,
- Related loop:
chr21:33625000-33650000~~chr21:33825000-33850000,
chr21:33625000-33650000~~chr21:33850000-33875000,
chr21:33675000-33700000~~chr21:33850000-33875000,
chr21:33825000-33850000~~chr21:38075000-38100000,
chr21:33850000-33875000~~chr21:33975000-34000000,
chr21:33850000-33875000~~chr21:34325000-34350000,
chr21:7800000-7825000~~chr21:33825000-33850000,