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Basic information

CohesinDB ID: CDBP00417522

Locus: chr21-33870720-33871769

Data sourse: GSE67783, GSE86191, GSE206145, ENCSR153HNT, GSE165895

Cell type: RPE, HCT-116, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: NIPBL,SA1,Rad21,SMC1,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 68%, "14_ReprPCWk": 12%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, FOXA1, NFIC, SMARCE1, TRIM28, SNAI2, NFE2L2, CTCF, TCF12, JUN, EP300, KLF1, DPF2, TRIM24, E2F1, TEAD4, FOXA3, POU2F2, CTBP1, MTA2, ZSCAN5A, DDX5, NBN, ASCL1, SMARCA4, ARID1B, GRHL3, NKX2-1, FOXK2, GABPA, STAT3, IKZF1, NFE2, RCOR1, CEBPB, KMT2A, EZH2, IRF1, HDAC2, GATA2, SMARCA5, MAFG, HDAC1, CEBPA, ZFX, SMAD3, RUNX2, NRF1, ARNT, ZEB2, CBFA2T3, FOS, MED1, CEBPD, ZMYM3, C11orf30, STAT5A, MAFK, ZBTB7A, BCOR, CBFA2T2, PPARG, CBX3, FOXA2, CREM, KDM1A, YY1, RELA, JUNB, ZFP36, HIF1A, TAL1, MAX, GATA1, NR2F1, NEUROG2, NFKB1, AR, EGLN2, NCOR1, RNF2, JUND, BRD4, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): CRYZL1,AP000311.1,ITSN1

Function elements

Human SNPs: Height

Number of somatic mutations (coding): 16

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000249209, ENSG00000205758, ENSG00000205726,

eachgene

Deatailed information for cohesin site CDBP00417522