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Basic information

CohesinDB ID: CDBP00417523

Locus: chr21-33873576-33876182

Data sourse: GSE67783, GSE86191, GSE98367, GSE111913, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, Monocytes, RT-112, K-562, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 63%, "14_ReprPCWk": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: BCL6, FOXA2, CEBPA, SOX13, ZFX, XBP1, FOXA1, TCF7, CDK9, HOXB13, HNF4G, KDM1A, ERG, RELA, ETS1, ZFP64, GRHL3, GATA3, PRDM9, GABPA, SMAD4, XRCC5, MAX, FOS, ZNF736, NR2F6, CEBPB, TEAD3, TEAD1, NR2F2, KMT2A, TERF1, TCF7L2, CEBPD, SCRT2, CTCF, SP1, EP300, BCL11A, HNF4A, BHLHE40, SOX5, MNT, HDAC2, ASH2L, SCRT1, FOXP1, TEAD4, FOXA3, ZNF175, GATAD2A, TFAP2C, EED

Target gene symbol (double-evidenced CRMs): AP000311.1,IFNAR2,IFNGR2,DONSON,AP000295.1,SON,ITSN1,CRYZL1

Function elements

Human SNPs: QT_interval

Number of somatic mutations (coding): 308

Number of somatic mutations (non-coding): 14

Related genes and loops

Related gene: ENSG00000249624, ENSG00000159110, ENSG00000159128, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726,

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Deatailed information for cohesin site CDBP00417523