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Basic information

CohesinDB ID: CDBP00417525

Locus: chr21-33877772-33878324

Data sourse: GSE67783, GSE98367, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT

Cell type: RPE, Fibroblast, Monocytes, K-562, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 68%, "14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MAFG, SMC1A, MTA3, ZFX, NME2, MAFF, DDX5, HOXB13, ERG, ARNT, ZSCAN4, FOS, MED1, CBX2, ZNF264, SNAI2, C11orf30, MAFK, JUND, ZIM3, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): AP000295.1,SON,IFNAR2,IFNGR2,ITSN1,AP000311.1,DONSON,CRYZL1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 16

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000249624, ENSG00000159110, ENSG00000159128, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726,

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Deatailed information for cohesin site CDBP00417525